CAJ | 학술논문

目的探讨将BMP-7作为骨性关节炎(osteoarthritis,OA)早期诊断潜在生物学标志的可能性.方法收集67例OA患者及23例非OA膝关节疾病患者(半月板损伤11例,前交叉韧带损伤9例,盘状半月板2例,髌骨半脱位1例,均无明显关节软骨损伤)的血清和关节滑液,采用Kellgren-Lawrence放射学分级标准对OA患者的影像学表现分级.酶联免疫吸附试验(ELISA)检测血清和关节滑液中BMP-7水平.结果 OA组血清、滑液中BMP-7水平高于非OA组(Pser<0.001, PSF=0.001),两组血清中BMP-7水平均高于滑液(P<0.001).OA组血清、滑液中BMP-7水平与OA严重程度相关(rser=0.788, Pser<0.001;rSF=0.766,PSF<0.001),血清BMP-7与滑液BMP-7水平呈正相关(r=0.817,P<0.001).结论 BMP-7可作为生物学标志用于OA的早期诊断及预后监测.
목적탐토장BMP-7작위골성관절염(osteoarthritis,OA)조기진단잠재생물학표지적가능성.방법수집67례OA환자급23례비OA슬관절질병환자(반월판손상11례,전교차인대손상9례,반상반월판2례,빈골반탈위1례,균무명현관절연골손상)적혈청화관절활액,채용Kellgren-Lawrence방사학분급표준대OA환자적영상학표현분급.매련면역흡부시험(ELISA)검측혈청화관절활액중BMP-7수평.결과 OA조혈청、활액중BMP-7수평고우비OA조(Pser<0.001, PSF=0.001),량조혈청중BMP-7수평균고우활액(P<0.001).OA조혈청、활액중BMP-7수평여OA엄중정도상관(rser=0.788, Pser<0.001;rSF=0.766,PSF<0.001),혈청BMP-7여활액BMP-7수평정정상관(r=0.817,P<0.001).결론 BMP-7가작위생물학표지용우OA적조기진단급예후감측.
Objective To study the possibility to use bone morphogenetic protein-7 (BMP-7) as a potential biomarker in early diagnosis of osteoarthritis (OA). Methods Plasma and synovial fluid (SF) samples were taken from 67 OA patients and 23 non-OA patients (11 meniscus injury patients, 9 anterior cruciate ligament injury patients, 2 discoid meniscus patients, and 1 patellar subluxation patient, with no significant articular cartilage lesion). Findings on their images were classified according to the Kellgren-Lawrence radiographic grading criteria. The BMP-7 levels in serum and SF were measured by ELISA. Results The BMP-7 levels in serum and SF were significantly higher in OA patients than in non-OA patients (P<0.001) and in serum than in SF (P<0.001), and correlated with the severity of OA (r=0.788, r=0.766, P<0.001). In addition, the BMP-7 levels in serum and SF were positively correlated with each other (r=0.817, P<0.001). Conclusion BMP-7 can be used as a biomarker in early diagnosis of OA and its prognosis monitoring.