检验医学与临床
檢驗醫學與臨床
검험의학여림상
JOURNAL OF LABORATORY MEDICINE AND CLINICAL SCIENCES
2013年
1期
9-10
,共2页
同型半胱氨酸%胱抑素C%β2‐微球蛋白%糖尿病肾病
同型半胱氨痠%胱抑素C%β2‐微毬蛋白%糖尿病腎病
동형반광안산%광억소C%β2‐미구단백%당뇨병신병
homocysteine%cystatin C%β2‐microglobulin%diabetic nepnropathy
目的探讨血清同型半胱氨酸、血清胱抑素C和尿β2‐微球蛋白联合检测对糖尿病肾病的临床价值.方法将102例糖尿病肾病患者按尿液清蛋白排泄率分为A、B、C 3组:正常清蛋白组(A组,n=42)、微量清蛋白组(B组,n=35)、大量清蛋白组(C组,n=25),同时以20例健康人作为健康对照组.分别检测血清同型半胱氨酸、血清胱抑素C、尿液清蛋白和尿β2‐微球蛋白水平,对检测结果采用SAS统计软件进行统计学处理作对比分析.结果糖尿病肾病患者各组间血清同型半胱氨酸、血清胱抑素C和尿β2‐微球蛋白检测值比较差异均有统计学意义(P<0.01).102例糖尿病肾病患者血清同型半胱氨酸、血清胱抑素C和尿β2‐微球蛋白检测值采用多元线性相关分析呈正相关(r为0.250,0.410,0.365;P<0.01).结论血清同型半胱氨酸、血清胱抑素C和尿β2‐微球蛋白联合检测可以推断糖尿病肾病的损害程度,更全面地评价早期糖尿病肾损害,提示临床应早期干预血清同型半胱氨酸水平.
目的探討血清同型半胱氨痠、血清胱抑素C和尿β2‐微毬蛋白聯閤檢測對糖尿病腎病的臨床價值.方法將102例糖尿病腎病患者按尿液清蛋白排洩率分為A、B、C 3組:正常清蛋白組(A組,n=42)、微量清蛋白組(B組,n=35)、大量清蛋白組(C組,n=25),同時以20例健康人作為健康對照組.分彆檢測血清同型半胱氨痠、血清胱抑素C、尿液清蛋白和尿β2‐微毬蛋白水平,對檢測結果採用SAS統計軟件進行統計學處理作對比分析.結果糖尿病腎病患者各組間血清同型半胱氨痠、血清胱抑素C和尿β2‐微毬蛋白檢測值比較差異均有統計學意義(P<0.01).102例糖尿病腎病患者血清同型半胱氨痠、血清胱抑素C和尿β2‐微毬蛋白檢測值採用多元線性相關分析呈正相關(r為0.250,0.410,0.365;P<0.01).結論血清同型半胱氨痠、血清胱抑素C和尿β2‐微毬蛋白聯閤檢測可以推斷糖尿病腎病的損害程度,更全麵地評價早期糖尿病腎損害,提示臨床應早期榦預血清同型半胱氨痠水平.
목적탐토혈청동형반광안산、혈청광억소C화뇨β2‐미구단백연합검측대당뇨병신병적림상개치.방법장102례당뇨병신병환자안뇨액청단백배설솔분위A、B、C 3조:정상청단백조(A조,n=42)、미량청단백조(B조,n=35)、대량청단백조(C조,n=25),동시이20례건강인작위건강대조조.분별검측혈청동형반광안산、혈청광억소C、뇨액청단백화뇨β2‐미구단백수평,대검측결과채용SAS통계연건진행통계학처리작대비분석.결과당뇨병신병환자각조간혈청동형반광안산、혈청광억소C화뇨β2‐미구단백검측치비교차이균유통계학의의(P<0.01).102례당뇨병신병환자혈청동형반광안산、혈청광억소C화뇨β2‐미구단백검측치채용다원선성상관분석정정상관(r위0.250,0.410,0.365;P<0.01).결론혈청동형반광안산、혈청광억소C화뇨β2‐미구단백연합검측가이추단당뇨병신병적손해정도,경전면지평개조기당뇨병신손해,제시림상응조기간예혈청동형반광안산수평.
Objective To explore application of serum homocysteine ,cystatin C and urine β2‐microglobulin joint detection in diabetic nephropathy .Methods The 102 cases of diabetic nephropathy were divided into A ,B ,C three groups by urinary albumin excretion rates :normal albumin group A (42 cases)、albumin group B (35 cases) , large amounts of albumin group C (25 cases) .At the same time to 20 healthy subjects served as normal control group .Serum homocysteine ,serum cystatin C ,urine protein and urineβ2‐microglobulin levels were detected .The de‐tection results were used the SAS statistical software to deal with statistics for comparative analysis .Results Serum homocysteine ,systatin C and urineβ2‐microglobulin were statistically different between diabetic nephropathy groups (P<0 .01) .Serum homocysteine ,serum cystatin C and urineβ2‐microglobulin detection values of 102 cases with dia‐betic nephropathy were analyzed by multiple linear correlation ,these were positive correlation (r= 0 .250 ,0 .410 , 0 .365 ,P<0 .01) .Conclusion Serum homcysteine ,serum cystatin C and urine β2‐microglobulin joint detection can infer diabetic nephropathy damage degree ,which can evaluate renal damage in diabetes and suggest clinical interven‐tion of blood homocysteine levels earlier .
