CAJ | 학술논문

目的探讨襄阳市中医医院耐甲氧西林金黄色葡萄球菌(MRSA)及耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)的临床分布特点及其耐药性,为临床治疗葡萄球菌属感染提供正确选药依据.方法对2011年1~12月襄阳市中医医院各临床科室送检的各类标本中分离鉴定出的MRSA及MRCNS ,采用琼脂纸片扩散(K‐B)法进行药敏试验,对其药敏结果进行统计及分析,并探讨其临床分布与耐药特点.结果分离出的328株金黄色葡萄球菌中,MRSA有230株,占70.1%,以重症监护病房为最多,其检出率为85.5%,其次为骨伤科及内分泌科,检出率分别为83.6%及81.3%;210株凝固酶阴性葡萄球菌中,MRCNS有132株,占62.9%,以骨伤科最多,其检出率为74.6%,其次为呼吸内科和内分泌科,其检出率分别为73.9%和66.7%;MRSA和MRCNS均对氨基糖苷类、喹诺酮类、磺胺类等抗菌药物呈多药耐药性;尚未发现耐糖肽类和利萘唑胺的菌株.结论及时了解MRSA、MRCNS感染的分布与特征,监测其耐药情况,有助于临床及时采取合理的防治措施,有效控制感染及扩散.
목적탐토양양시중의의원내갑양서림금황색포도구균(MRSA)급내갑양서림응고매음성포도구균(MRCNS)적림상분포특점급기내약성,위림상치료포도구균속감염제공정학선약의거.방법대2011년1~12월양양시중의의원각림상과실송검적각류표본중분리감정출적MRSA급MRCNS ,채용경지지편확산(K‐B)법진행약민시험,대기약민결과진행통계급분석,병탐토기림상분포여내약특점.결과분리출적328주금황색포도구균중,MRSA유230주,점70.1%,이중증감호병방위최다,기검출솔위85.5%,기차위골상과급내분비과,검출솔분별위83.6%급81.3%;210주응고매음성포도구균중,MRCNS유132주,점62.9%,이골상과최다,기검출솔위74.6%,기차위호흡내과화내분비과,기검출솔분별위73.9%화66.7%;MRSA화MRCNS균대안기당감류、규낙동류、광알류등항균약물정다약내약성;상미발현내당태류화리내서알적균주.결론급시료해MRSA、MRCNS감염적분포여특정,감측기내약정황,유조우림상급시채취합리적방치조시,유효공제감염급확산.
Objective To discuss the metrically‐resistant Staphylococcus aurum s (MRSA) and the metrically resistant coagulate negative Staphylococci s (MRCNS) clinical distribution and drug resistance of our hospital ,and to provide the correct basis of medicine choice for clinical treatment on Staph infection .Methods From January 2011 to December ,MRSA and MRCNS that were separated and identified by a variety of samples from our clinical depart‐ments for drug sensitive test by K‐B method .The results of drug susceptibility were analyzed statistically .Drug re‐sistance characteristics and clinical distribution were discussed .Results The separation of the 328 strains of staphy‐lococcus aurous ,230 strains were MRSA ,accounting for 70 .1% ,the most of them were in ICU ,the positive rate was 85 .5% ,then were in orthopedics and traumatology department and endocrine division ,positive detection rates were 83 .6% and 81 .3% ,respectively .210 plants solidify enzyme negative staphylococcus aurous ,132 strains were MRC‐NS ,accounting for 62 .9% ,most of them were in orthopedics ,the positive detection rate was 74 .6% ,and then were in breathing physicians and endocrine division ,positive detection rates were 73 .9% and 66 .7% .MRSA and MRCNS were resistant to amino glycoside ,quinolone antibacterial drugs ,sulfa etc and showed the multiple drug resistance .No strain was found resistant to sugar peptide and naphthalene amine .Conclusion Understanding the distribution and characteristics of MRSA and MRCNS′s infection promptly ,monitoring the drug resistance of them ,can help to take reasonable prevention and control measures in clinical medicine ,and also control infection spreading effectively .