CAJ | 학술논문

目的探讨急性脑梗死(ACI)患者血清chemerin检测的临床意义.方法用酶联免疫吸附试验法检测78例ACI患者(ACI组)和70例健康体检者(对照组)血清chemerin水平.同时测量其体质量指数、空腹血糖、血脂和C反应蛋白(CRP)等生化指标,并对脑梗死患者进行美国国立卫生院神经功能缺损评分(NIHSS).结果与对照组比较,ACI组血清chemerin水平升高,其升高水平与体质量指数、CRP、空腹血糖、三酰甘油、低密度脂蛋白胆固醇和NIHSS呈显著正相关.结论 ACI患者血清chemerin水平升高,chemerin可能通过影响胰岛素抵抗、血脂代谢,参与炎症反应和动脉粥样硬化等机制在脑梗死的发生中起重要作用.
목적탐토급성뇌경사(ACI)환자혈청chemerin검측적림상의의.방법용매련면역흡부시험법검측78례ACI환자(ACI조)화70례건강체검자(대조조)혈청chemerin수평.동시측량기체질량지수、공복혈당、혈지화C반응단백(CRP)등생화지표,병대뇌경사환자진행미국국립위생원신경공능결손평분(NIHSS).결과여대조조비교,ACI조혈청chemerin수평승고,기승고수평여체질량지수、CRP、공복혈당、삼선감유、저밀도지단백담고순화NIHSS정현저정상관.결론 ACI환자혈청chemerin수평승고,chemerin가능통과영향이도소저항、혈지대사,삼여염증반응화동맥죽양경화등궤제재뇌경사적발생중기중요작용.
Objective To investigate the clinical significance of serum chemerin levels after acute cerebral in‐farction .Methods Serum chemerin levels within 72 hours were detected by ELISA in ischemic strokes (ACI group , 78 cases) and healthy controls(Control group ,70 cases) .The body mass index (BMI) ,fasting blood glucose(FBG) , blood lipids and C‐reactive protein(CRP) were analyzed as well .Initial stroke severity was also assessed by the Na‐tional Institutes of Health Stroke Scale (NIHSS) .Results Compared with control group ,serum chemerin levels in ACI group significantly elevated and positively correlated with BMI ,CPR ,FBG ,triglyceride(TG) ,low density lipo‐protein cholesterol(LDL‐C) and the NIHSS .Conclusion Serum chemerin levels elevated after ischemic stroke could play a fundamental role in the pathogenesis of cerebral infarction through regulating insulin resistance ,lipid metabo‐lism ,inflammatory processes and atherosclerosis .