CAJ | 학술논문

肺脏干细胞是一类重要的成体干细胞,对于维持肺脏稳态、肺损伤后的修复发挥关键的作用.作者总结了现有采用流式细胞分选和小鼠的谱系追踪模型,在成年肺的不同解剖位置鉴定不同的肺干/祖细胞亚群的最新进展,对于更进一步了解肺损伤后的修复、肺疾病的发病机制以及鉴定肿瘤的来源细胞至关重要的意义.本文指出:从肺的发育角度研究肺的再生和激活肺损伤后修复的相关信号通路将为加深对肺干/祖细胞的认识,促进再生医学发展具有十分重要的意义.
폐장간세포시일류중요적성체간세포,대우유지폐장은태、폐손상후적수복발휘관건적작용.작자총결료현유채용류식세포분선화소서적보계추종모형,재성년폐적불동해부위치감정불동적폐간/조세포아군적최신진전,대우경진일보료해폐손상후적수복、폐질병적발병궤제이급감정종류적래원세포지관중요적의의.본문지출:종폐적발육각도연구폐적재생화격활폐손상후수복적상관신호통로장위가심대폐간/조세포적인식,촉진재생의학발전구유십분중요적의의.
Lung stem cells are an important kind of adult stem cells, which play a key role in the maintenance of homeostasis and repair after injure of lung. In this paper, we summarized the latest progress of characterization of different lung stem/progenitor cell subgroups in distinct anatomic sites in adult mouse lungs based on flow cell sorting and lineage tracing, which are of great importance to reveal out the mechanisms of repair after lung injury and nosogenesis of lung disease, and cellular resource of tumors. At last we prospected that it is important to study the regeneration of lung and activation of repair-related signaling pathways after injury in terms of development for deepening the knowledge of lung stem/progenitor cells and development of regenerative medicine.