CAJ | 학술논문

目的筛选双料喉风散保留灌肠治疗溃疡性直肠炎的最佳方案,形成规范化操作,以提高临床疗效.方法选择160例轻、中度溃疡性直肠炎患者作为研究对象,按照药液温度(37~39℃/40~41℃)、药量(1.1/2.2 g)、灌肠材料(肛管/吸痰管)、灌肠姿势(左侧卧位/胸膝体位)、导管插入深度(10~15 cm/根据肠镜结果插入15~25 cm)、保留灌肠时间(≥6 h/<6 h)及疗程(2/4周)7因素2水平,利用L8(27)正交试验安排试验,把纳入的患者分为8组.使用疾病活动指数进行疗效判定,以找出最优化的灌肠治疗方案.结果双料喉风散溶液灌肠治疗溃疡性直肠炎的最佳方案为:保留灌肠药液温度为40~41℃,药量为2.2 g,灌肠材料使用吸痰管,灌肠时患者采取胸膝体位,插管深度根据肠镜结果插入15~25 cm,灌肠液保留时间≥6 h,灌肠疗程4周.结论在这7个灌肠影响因素中,灌肠药液保留时间为影响临床疗效的最主要因素,其余影响因素作用不明显.
목적사선쌍료후풍산보류관장치료궤양성직장염적최가방안,형성규범화조작,이제고림상료효.방법선택160례경、중도궤양성직장염환자작위연구대상,안조약액온도(37~39℃/40~41℃)、약량(1.1/2.2 g)、관장재료(항관/흡담관)、관장자세(좌측와위/흉슬체위)、도관삽입심도(10~15 cm/근거장경결과삽입15~25 cm)、보류관장시간(≥6 h/<6 h)급료정(2/4주)7인소2수평,이용L8(27)정교시험안배시험,파납입적환자분위8조.사용질병활동지수진행료효판정,이조출최우화적관장치료방안.결과쌍료후풍산용액관장치료궤양성직장염적최가방안위:보류관장약액온도위40~41℃,약량위2.2 g,관장재료사용흡담관,관장시환자채취흉슬체위,삽관심도근거장경결과삽입15~25 cm,관장액보류시간≥6 h,관장료정4주.결론재저7개관장영향인소중,관장약액보류시간위영향림상료효적최주요인소,기여영향인소작용불명현.
Objective To work out the best plan for treatment of ulcerative rectitis by Shuangliaohoufengsan retention enema and to provide evidence for standardized technique. Methods With L8 (27) orthogonal experiment, 160 patients with mild or moderate ulcerative rectitis were divided into 8 groups in accordance with solution temperature (37~39℃/40~41℃), dosage (1.1 g/2.2 g), enema material (anal tube/suction tube), position (left recumbent/knee-chest), tube insertion depth (10~15 cm/15~25cm according to enteroscopy result), time for retention enema (≥6 h/< 6 h) and period of treatment (2 weeks/4 weeks). The treatment effects were determined by disease activity index. Results The best plan of treating ulcerative rectitis by Shuangliaohoufengsan enema included factors such as enema solution with temperature between 40~41℃, dosage of 2.2 g, suction tube, knee-chest position, tube insertion depth of 15~25 cm according to enteroscopy result, time for retention enema≥6 h, 4-week treatment period. Conclusion Among the 7 factors, solution retention time is the main factor affecting the clinical result of enema but the effects of other factors are inconspicuous.