生物骨科材料与临床研究
生物骨科材料與臨床研究
생물골과재료여림상연구
ORTHOPAEDIC BIOMECHANICS MATERIALS AND CLINICAL STUDY
2013年
2期
1-4
,共4页
内环境稳态%细胞膜电容放电%生物电能%蛋白聚糖及胶原纤维%骨折%应力遮挡
內環境穩態%細胞膜電容放電%生物電能%蛋白聚糖及膠原纖維%骨摺%應力遮擋
내배경은태%세포막전용방전%생물전능%단백취당급효원섬유%골절%응력차당
Chitosan%Water soluble O-hydroxyethyl chitosan%Polylactic acid%Graft copolymer
目的探讨"组织细胞生物电能稳态失衡"概念与骨折内固定后出现应力遮挡综合症发生发展的关系.方法引入一个新的概念,即"组织细胞内环境生物电能稳态"(或"骨组织内单位体积生物电能含量稳态").这个概念包括骨组织细胞外基质中蛋白聚糖分子生物电能的储存量、细胞膜膜电位以及细胞内负离子含量要维持在一个正常范围.通过这一新理论阐述应力遮挡形成原因的关系.结果骨折内固定(钢板或带锁髓内钉)出现不同程度的应力遮挡现象,应力遮挡区域骨组织出现单位体积内生物电能含量不足,并且处于长期、持续性生物电能含量减低现象,导致内固定应力遮挡范围内骨组织生物电能稳态失衡,骨组织处于长期、持续性极其轻度的酸化环境中,最终出现骨组织局部骨质疏松.结论骨组织单位体积内生物电能含量持续性减低是导致骨质疏松、骨愈合缓慢(应力遮挡)的原因.
目的探討"組織細胞生物電能穩態失衡"概唸與骨摺內固定後齣現應力遮擋綜閤癥髮生髮展的關繫.方法引入一箇新的概唸,即"組織細胞內環境生物電能穩態"(或"骨組織內單位體積生物電能含量穩態").這箇概唸包括骨組織細胞外基質中蛋白聚糖分子生物電能的儲存量、細胞膜膜電位以及細胞內負離子含量要維持在一箇正常範圍.通過這一新理論闡述應力遮擋形成原因的關繫.結果骨摺內固定(鋼闆或帶鎖髓內釘)齣現不同程度的應力遮擋現象,應力遮擋區域骨組織齣現單位體積內生物電能含量不足,併且處于長期、持續性生物電能含量減低現象,導緻內固定應力遮擋範圍內骨組織生物電能穩態失衡,骨組織處于長期、持續性極其輕度的痠化環境中,最終齣現骨組織跼部骨質疏鬆.結論骨組織單位體積內生物電能含量持續性減低是導緻骨質疏鬆、骨愈閤緩慢(應力遮擋)的原因.
목적탐토"조직세포생물전능은태실형"개념여골절내고정후출현응력차당종합증발생발전적관계.방법인입일개신적개념,즉"조직세포내배경생물전능은태"(혹"골조직내단위체적생물전능함량은태").저개개념포괄골조직세포외기질중단백취당분자생물전능적저존량、세포막막전위이급세포내부리자함량요유지재일개정상범위.통과저일신이론천술응력차당형성원인적관계.결과골절내고정(강판혹대쇄수내정)출현불동정도적응력차당현상,응력차당구역골조직출현단위체적내생물전능함량불족,병차처우장기、지속성생물전능함량감저현상,도치내고정응력차당범위내골조직생물전능은태실형,골조직처우장기、지속성겁기경도적산화배경중,최종출현골조직국부골질소송.결론골조직단위체적내생물전능함량지속성감저시도치골질소송、골유합완만(응력차당)적원인.
@@@@Objective To investigate the relationship between biological energy homeostasis of tissue and cell and stress shielding syndrome after fracture internal fixation. Method To introduct a new concept, named"the tissue cells envi-ronment bio-energy steady state" (or"bio-energy steady state in the unit volume of bone tissue"). This concept includes the amount of biological energy storage in the bone tissue extracellular matrix proteoglycan molecules, membrane poten-tial and intracellular anion content which is to be maintained in a normal range. Through this new theory, the causes of stress shielding is revealed. Results Fracture internal fixation (steel plate or interlocking intramedullary nail) appears in varying degrees of stress shielding phenomenon. Per unit volume of bone tissue in stress shielding region appears in-sufficient bio-energy content. In the long-term, persistent bio-energy content reduction results in the bone tissue acidi-fication and eventually local osteoporosis. Conclusion The biological energy content reduction in per unit volume of bone tissue is due to osteoporosis and slow healing of the bone (stress shielding).
