CAJ | 학술논문

背景:随着新型肾损伤标志物的不断发现及其在不同肾脏疾病中的表达及作用机制的阐明,肾损伤防治取得了重要进展.目的:综述肾损伤标志物的研究进展.方法:应用计算机检索2006年1月2011年10月 PubMed 数据库相关文章,检索词为“renal injury,markers”,并限定文章语言种类为 English.同时计算机检索2006年1月2011年10月中国期刊全文数据库相关文章,检索词为“肾损伤,标志物”,并限定文章语言种类为中文.此外手工检索相关中英文会议文集.最终纳入符合标注的文献50篇.结果与结论:肾损伤标志物在不同肾疾病中的预测及表达不同,按时间、结构、功能及标本来源可将其进行不同的划分.这些标志物不仅能早期监测肾脏疾病、评估急性肾损伤,且有助于判断慢性肾损伤的转归.近年来发现的肾损伤标志物其变化均较血肌酐早,且具有较高的灵敏性和特异性,但如何筛选并应用于临床,还需深入研究其在不同个体、不同时相及不同合并症或并发症影响下的变化情况,建立肾损伤的预警平台,以期达到早期诊断和治疗肾损伤的目的.
배경:수착신형신손상표지물적불단발현급기재불동신장질병중적표체급작용궤제적천명,신손상방치취득료중요진전.목적:종술신손상표지물적연구진전.방법:응용계산궤검색2006년1월2011년10월 PubMed 수거고상관문장,검색사위“renal injury,markers”,병한정문장어언충류위 English.동시계산궤검색2006년1월2011년10월중국기간전문수거고상관문장,검색사위“신손상,표지물”,병한정문장어언충류위중문.차외수공검색상관중영문회의문집.최종납입부합표주적문헌50편.결과여결론:신손상표지물재불동신질병중적예측급표체불동,안시간、결구、공능급표본래원가장기진행불동적화분.저사표지물불부능조기감측신장질병、평고급성신손상,차유조우판단만성신손상적전귀.근년래발현적신손상표지물기변화균교혈기항조,차구유교고적령민성화특이성,단여하사선병응용우림상,환수심입연구기재불동개체、불동시상급불동합병증혹병발증영향하적변화정황,건립신손상적예경평태,이기체도조기진단화치료신손상적목적.
BACKGROUND: With the development of new renal injury markers as wel as the expression and mechanism in different renal diseases, an important progress has achieved in the protection of renal disease. OBJECTIVE: To summarize the research progress of renal injury markers. METHODS: The PubMed database was searched using the computer for articles published from January 2006 to October 2011 using the key words of “renal injury, markers” in English. Simultaneously, China Journal Ful -text database were retrieved for articles published from January 2006 to October 2011 using the key words of “renal injury, markers” in Chinese. Besides, Conference Proceedings of English and Chinese were retrieved by hand. Final y, 50 articles were included according to the inclusion criteria. RESULTS AND CONCLUSION: The prediction and expression of the renal injury markers in different renal disease is distinct. According to time, the renal injury markers can be divided into acute and chronic kidney damage; according to the structure and function, the markers can be divided into glomerular, tubular and glomerular filtration rate; according to the source of specimen, the markers can be divided into blood, urine and tissue biopsy. These markers can not only early detect kidney disease, assess acute kidney injury and can determine the outcome of chronic renal injury. The diversification of renal injury markers is earlier than that of serum creatinine, and the renal injury markers have high sensitivity and specificity, but the screening and clinical application of renal injury markers needs further study on the changes in different individuals, different phase and different comorbidities or complications of kidney damage, and establish the early warning platform in order to achieve the purpose of early diagnosis and treatment of renal injury.