CAJ | 학술논문

背景与目的:SPARC类似蛋白1(SPARC-like 1,SPARCL1)是细胞外基质蛋白SPARC相关家族成员,在多种肿瘤细胞中低表达,有肿瘤抑制作用.本研究探讨其在胆管癌中的表达及与预后的关系.方法:采用组织芯片和免疫组织化学技术检测胆管癌和部分癌旁非肿瘤组织中SPARCL1蛋白的表达,并分析其与各项临床病理参数及患者预后的关系.结果:免疫组化结果显示,SPARCL1在胆管癌中的表达率为47.9%(23/48),在癌旁胆管上皮中均有表达.SPARCL1的表达与区域淋巴结转移和神经侵犯呈负相关,生存期分析显示SPARCL1阳性患者预后明显优于阴性患者(37.3 vs 12.8个月,P<0.001).结论:SPARCL1在胆管癌的发生发展过程中起着重要作用,是影响胆管癌患者预后的重要因素.
배경여목적:SPARC유사단백1(SPARC-like 1,SPARCL1)시세포외기질단백SPARC상관가족성원,재다충종류세포중저표체,유종류억제작용.본연구탐토기재담관암중적표체급여예후적관계.방법:채용조직심편화면역조직화학기술검측담관암화부분암방비종류조직중SPARCL1단백적표체,병분석기여각항림상병리삼수급환자예후적관계.결과:면역조화결과현시,SPARCL1재담관암중적표체솔위47.9%(23/48),재암방담관상피중균유표체.SPARCL1적표체여구역림파결전이화신경침범정부상관,생존기분석현시SPARCL1양성환자예후명현우우음성환자(37.3 vs 12.8개월,P<0.001).결론:SPARCL1재담관암적발생발전과정중기착중요작용,시영향담관암환자예후적중요인소.
@@@@Background and purpose:SPARC-like 1 (SPARCL1) is a member of extracellular matrix protein SPARC family, it was found to be down-expressed and had tumor inhibitory role in several cancers. This study aimed to investigate the SPARCL1 expression and determine its clinical significance in cholangiocarcinoma. Methods:Tissue microarray blocks containing tumor specimens obtained from 48 patients were constructed. Expressions of SPARCL1 in these specimens were detected by immunohistochemistry (IHC) method. Results:IHC showed that expression of SPARCL1 was observed in 23 cases (47.9%) of 48 primary tumors. SPARCL1 expression was significantly inversely associated with lymph node metastases and nerve invasion. Loss of SPARCL1 expression significantly correlated with poor survival in univariate analysis (37.3 vs 12.8 months, P<0.001). Conclusion:Our results showed SPARCL1 expression significantly changed in cholangiocarcinoma, and suggested the importance of SPARCL1 as a biomarker in cancer development and progression.