CAJ | 학술논문

背景与目的:组织因子(tissuefactor,TF)、基质金属蛋白酶-9(matrix metalloproteinase-9,MMP-9)是影响乳腺癌转移和预后的重要因子,蛋白酶激活受体-2(proteinase activated receptor-2,PAR-2)是二者之间的介导因子.本研究旨在探讨乳腺癌组织中TF、PAR-2和MMP-9表达的变化与乳腺癌新辅助化疗疗效的关系.方法:应用二步法免疫组织化学方法检测85例乳腺癌新辅助化疗前后乳腺癌组织中TF、PAR-2和MMP-9的表达,分析新辅助化疗前后其表达的变化与新辅助化疗疗效的关系.结果:85例乳腺癌新辅助化疗患者病理完全缓解率(G5)为8.3%,其他患者在新辅助化疗后TF、PAR-2和MMP-9阳性率均降低,其中MMP-9显著降低(P<0.05).新辅助化疗后,MMP-9表达阳性减弱的患者病理疗效显著好于阳性增强者(P<0.05);TF、MMP-9由阳性转为阴性患者的病理疗效显著好于由阴性转为阳性患者(P<0.05).PAR-2的改变则与病理疗效无显著关系.结论:乳腺癌新辅助化疗后TF、MMP-9的阳性表达降低与病理缓解率相关,有助于判断新辅助化疗疗效.
배경여목적:조직인자(tissuefactor,TF)、기질금속단백매-9(matrix metalloproteinase-9,MMP-9)시영향유선암전이화예후적중요인자,단백매격활수체-2(proteinase activated receptor-2,PAR-2)시이자지간적개도인자.본연구지재탐토유선암조직중TF、PAR-2화MMP-9표체적변화여유선암신보조화료료효적관계.방법:응용이보법면역조직화학방법검측85례유선암신보조화료전후유선암조직중TF、PAR-2화MMP-9적표체,분석신보조화료전후기표체적변화여신보조화료료효적관계.결과:85례유선암신보조화료환자병리완전완해솔(G5)위8.3%,기타환자재신보조화료후TF、PAR-2화MMP-9양성솔균강저,기중MMP-9현저강저(P<0.05).신보조화료후,MMP-9표체양성감약적환자병리료효현저호우양성증강자(P<0.05);TF、MMP-9유양성전위음성환자적병리료효현저호우유음성전위양성환자(P<0.05).PAR-2적개변칙여병리료효무현저관계.결론:유선암신보조화료후TF、MMP-9적양성표체강저여병리완해솔상관,유조우판단신보조화료료효.
@@@@Background and purpose: TF and MMP-9 are important factors for prognosis and metastasis of breast cancer, PAR-2 is the mediate factor of them, this study aimed to evaluate the change of expressions of TF PAR-2 and MMP-9 in breast cancer patients after neoadjuvant chemotherapy and their correlations with pathologic response. Methods: The expressions of TF, PAR-2 and MMP-9 in 85 breast cancer tissues were examined by immunohistochemical technique (SP) before and after neoadjuvant chemotherapy. Correlation analysis were made between the change of expressions and pathologic response. Results: The strictly pathologic completely response rate (G5) was 8.3% in 85 breast cancer patients after neoadjuvant chemotherapy. The decrease of expression of MMP-9 after neoadjuvant chemotherapy was statistically significant correlations with pathological response (P<0.05). The expression changes of TF and MMP-9 from positive to negative was statistically significant correlated with tumor pathological response(P<0.05). The expression change of PAR-2 showed rarely significant (P>0.05). Conclusion: The decrease of expression of TF and MMP-9 after neoadjuvant chemotherapy have statistically significant correlations with pathological response, would be probably useful for estimating the effect of neoadjuvant chemotherapy.