中国癌症杂志
中國癌癥雜誌
중국암증잡지
CHINA ONCOLOGY
2013年
3期
229-234
,共6页
郑璐%马学军%王建华%许权%张三典%胡静
鄭璐%馬學軍%王建華%許權%張三典%鬍靜
정로%마학군%왕건화%허권%장삼전%호정
鼻腔NK/T细胞淋巴瘤%调强放疗%治疗疗效%不良反应
鼻腔NK/T細胞淋巴瘤%調彊放療%治療療效%不良反應
비강NK/T세포림파류%조강방료%치료료효%불량반응
Nasal natural killer/T-cell lymphoma%Intensity-modulated radiotherapy%Treatment outcome%Toxicity
背景与目的:放射治疗是早期鼻腔NK/T细胞淋巴瘤的主要治疗手段.近年来,越来越多的研究表明,在头颈部肿瘤的放射治疗中,调强放射治疗(intensity-modulated radiotherapy,IMRT)较常规放疗具有优势.本研究比较IMRT与常规放疗治疗早期鼻腔NK/T细胞淋巴瘤患者的疗效和急、慢性不良反应.方法:系统分析2005年5月—2011年11月在宁波市李惠利医院行常规放疗以及IMRT的ⅠE~ⅡE期鼻腔NK/T细胞淋巴瘤患者46例,分为IMRT组(14例)和常规放疗组(32例).常规放疗射野靶区包括双侧鼻腔、筛窦、硬腭和同侧上颌窦,颈部淋巴结受侵时加做双颈照射,靶区剂量(50~54)Gy/(25~27)f,2.0 Gy/f;IMRT在CT下勾画靶区,剂量给予54 Gy/27 f,2.0 Gy/f.比较IMRT和常规放疗治疗早期鼻腔NK/T细胞淋巴瘤的疗效和不良反应.结果:IMRT组与常规放疗组的完全缓解率分别为78.6%和68.8%,差异无统计学意义(P>0.05);IMRT组与常规放疗组的3年总生存率(overall survival,OS)分别为71.4%和62.5%,差异无统计学意义(P>0.05).IMRT组的急性不良反应较常规放疗组轻(P<0.05);IMRT组患者晚期损伤中口干程度和味觉改变方面较常规放疗组减轻,而听力及视力损伤、脑损伤发生率等差异无统计学意义(P>0.05).结论:IMRT与常规放疗相比,临床疗效满意,同时能够减轻急性不良反应,降低部分晚期损伤发生率,有望改善患者的生存质量.
揹景與目的:放射治療是早期鼻腔NK/T細胞淋巴瘤的主要治療手段.近年來,越來越多的研究錶明,在頭頸部腫瘤的放射治療中,調彊放射治療(intensity-modulated radiotherapy,IMRT)較常規放療具有優勢.本研究比較IMRT與常規放療治療早期鼻腔NK/T細胞淋巴瘤患者的療效和急、慢性不良反應.方法:繫統分析2005年5月—2011年11月在寧波市李惠利醫院行常規放療以及IMRT的ⅠE~ⅡE期鼻腔NK/T細胞淋巴瘤患者46例,分為IMRT組(14例)和常規放療組(32例).常規放療射野靶區包括雙側鼻腔、篩竇、硬腭和同側上頜竇,頸部淋巴結受侵時加做雙頸照射,靶區劑量(50~54)Gy/(25~27)f,2.0 Gy/f;IMRT在CT下勾畫靶區,劑量給予54 Gy/27 f,2.0 Gy/f.比較IMRT和常規放療治療早期鼻腔NK/T細胞淋巴瘤的療效和不良反應.結果:IMRT組與常規放療組的完全緩解率分彆為78.6%和68.8%,差異無統計學意義(P>0.05);IMRT組與常規放療組的3年總生存率(overall survival,OS)分彆為71.4%和62.5%,差異無統計學意義(P>0.05).IMRT組的急性不良反應較常規放療組輕(P<0.05);IMRT組患者晚期損傷中口榦程度和味覺改變方麵較常規放療組減輕,而聽力及視力損傷、腦損傷髮生率等差異無統計學意義(P>0.05).結論:IMRT與常規放療相比,臨床療效滿意,同時能夠減輕急性不良反應,降低部分晚期損傷髮生率,有望改善患者的生存質量.
배경여목적:방사치료시조기비강NK/T세포림파류적주요치료수단.근년래,월래월다적연구표명,재두경부종류적방사치료중,조강방사치료(intensity-modulated radiotherapy,IMRT)교상규방료구유우세.본연구비교IMRT여상규방료치료조기비강NK/T세포림파류환자적료효화급、만성불량반응.방법:계통분석2005년5월—2011년11월재저파시리혜리의원행상규방료이급IMRT적ⅠE~ⅡE기비강NK/T세포림파류환자46례,분위IMRT조(14례)화상규방료조(32례).상규방료사야파구포괄쌍측비강、사두、경악화동측상합두,경부림파결수침시가주쌍경조사,파구제량(50~54)Gy/(25~27)f,2.0 Gy/f;IMRT재CT하구화파구,제량급여54 Gy/27 f,2.0 Gy/f.비교IMRT화상규방료치료조기비강NK/T세포림파류적료효화불량반응.결과:IMRT조여상규방료조적완전완해솔분별위78.6%화68.8%,차이무통계학의의(P>0.05);IMRT조여상규방료조적3년총생존솔(overall survival,OS)분별위71.4%화62.5%,차이무통계학의의(P>0.05).IMRT조적급성불량반응교상규방료조경(P<0.05);IMRT조환자만기손상중구간정도화미각개변방면교상규방료조감경,이은력급시력손상、뇌손상발생솔등차이무통계학의의(P>0.05).결론:IMRT여상규방료상비,림상료효만의,동시능구감경급성불량반응,강저부분만기손상발생솔,유망개선환자적생존질량.
@@@@Background and purpose: Radiotherapy is the main treatment strategy of early stage nasal natural killer(NK)/T-cell lymphoma. Recently, several studies have shown that intensity-modulated radiotherapy (IMRT) is superior to conventional radiotherapy in the treatment of head and neck cancer. The aim of the present study was to compare the therapeutic efficacy and acute and late adverse toxicities in patients with early stage nasal NK/T-cell lymphoma receiving conventional external beam radiation therapy (CRT) versus IMRT. Methods: Forty-six patients with localized stage ⅠE and ⅡE nasal NK/T-cell lymphoma treated in Lihuili Hospital between May 2005 and Nov. 2011 were systemically reviewed. Of all the patients, 32 patients received conventional radiotherapy (CRT group) and 14 received IMRT (IMRT group). Clinical treatment volume included bilateral nasal cavity, paranasal sinus and bilateral cervical region while cervical lymph node involved, two dimensional fields were applied to the patients in the CRT group with a total dose of 50-54 Gy in 25-27 fractions. Patients in IMRT group received 54 Gy in 27 fractions. Therapeutic efficacy and adverse effects were observed and compared between CRT and IMRT groups. Results: The CR rate of CRT and IMRT groups were 68.8% and 78.6%, respectively(P>0.05),the 3-year-overall survival (OS) of IMRT group was 71.4 %, comparing 62.5 % of CRT group(P>0.05). Statistical difference was not found in either CR rate or survival. The acute reactions like dry mouth, odynophagia, dysphagia, dermatitis and mucositis were observed in CRT and IMRT groups, less severe toxicities were notified in IMRT group with statistically significant difference (P<0.05). Xerostomia and taste alteration were less in IMRT group than those in CRT group, whereas the severity of acoustic/optic impairments and late brain injury were not significantly different in both groups. Conclusion: Treatment outcomes in the IMRT and CRT groups were comparable, while fewer acute reactions and some of late toxicities were observed in the IMRT group, and potential improved quality of life can be achieved in patients with IMRT technique.