CAJ | 학술논문

目的探讨艾司西酞普兰并富马酸喹硫平治疗伴有躯体化症状抑郁症的临床疗效及安全性.方法将80例抑郁症患者随机分成两组各40例,研究组应用艾司西酞普兰并喹硫平治疗,对照组单用艾司西酞普兰治疗,总疗程6周.应用17项汉密尔顿抑郁量表(HAMD-17)、14项汉密尔顿焦虑量表(HAMA-14)评定疗效,不良反应量表(TESS)及有关实验室检查评定不良反应.结果治疗6周后,研究组有效率为92.5%,与对照组比较差异有显著性(P <0.05).两组治疗后HAMD、HAMA评分比较差异有显著性(P <0.05),研究组TESS评分与对照组比较,差异无显著性(P >0.05),不良反应轻微.结论艾司西酞普兰合并喹硫平治疗伴躯体化症状的抑郁症安全、有效,值得临床推广使用.
목적탐토애사서태보란병부마산규류평치료반유구체화증상억욱증적림상료효급안전성.방법장80례억욱증환자수궤분성량조각40례,연구조응용애사서태보란병규류평치료,대조조단용애사서태보란치료,총료정6주.응용17항한밀이돈억욱량표(HAMD-17)、14항한밀이돈초필량표(HAMA-14)평정료효,불량반응량표(TESS)급유관실험실검사평정불량반응.결과치료6주후,연구조유효솔위92.5%,여대조조비교차이유현저성(P <0.05).량조치료후HAMD、HAMA평분비교차이유현저성(P <0.05),연구조TESS평분여대조조비교,차이무현저성(P >0.05),불량반응경미.결론애사서태보란합병규류평치료반구체화증상적억욱증안전、유효,치득림상추엄사용.
Objective To study the efficacy and safety of escitalopram combined with quetiapined in the treatment of depression with physical symptoms. Methods The 80 patients with depression were randomly divided into 2 groups(40 patients in escitalopram combined with quetiapined group, 40 patients in escitalopram group), The course was 6 weeks. Clinical effectiveness was evaluated using HAMD-17, HAMA-14, and adverse reactions and safety were assessed with TESS and laboratory examination. Result In the end of the treatment, the response rate was 92.5% for escitalopram combined with quetiapined group, there was significant difference of the efficacy(P <0.05). The difference in HAMD and HAMA score after treatment was significant(P <0.05), the difference in side effects between the two grous was not significant(P >0.05). Conclusion Escitalopram combined with quetiapine for depression with physical symptoms is an effective and safe therapy.