CAJ | 학술논문

目的:探讨胱抑素C(CystatinC,CysC)和视黄醇结合蛋白(Retinol-Binding Protein,RBP)浓度变化在评估肺癌化疗患者早期肾损伤中的临床价值.方法:采用免疫比浊法分别测定第一疗程第一、二周期32例肺癌化疗患者血清CysC和RBP的浓度,同时测定血清肌酐(Crea)及尿素(BUN)的浓度,以100例健康体检者为对照.结果:经两个周期的化疗,CysC浓度明显升高,与化疗前和对照组相比差异有统计学意义(P<0.05),第二周期与第一周期同期相比CysC浓度差异有统计学意义(P<0.05).RBP浓度明显升高,与化疗前和对照组相比差异有统计学意义(P<0.05),但第二周期与第一周期同期相比RNP浓度差异无统计学意义(P>0.05).BUN、Crea水平仅在化疗后第二周期略有升高,与化疗前和对照组相比差异有统计学意义(P<0.01);与第一周期同期相比差异有统计学意义(P<0.05).经直线相关性分析显示:CysC和RBP含量变化与eGFR呈负相关(P<0.05).结论:与正常对照相比,化疗诱发早期肾损伤的患者其血清CysC和RBP浓度明显升高,检测血清CysC和RBP浓度有助于化疗诱发早期肾损伤的诊断,具有较高的临床应用价值.
목적:탐토광억소C(CystatinC,CysC)화시황순결합단백(Retinol-Binding Protein,RBP)농도변화재평고폐암화료환자조기신손상중적림상개치.방법:채용면역비탁법분별측정제일료정제일、이주기32례폐암화료환자혈청CysC화RBP적농도,동시측정혈청기항(Crea)급뇨소(BUN)적농도,이100례건강체검자위대조.결과:경량개주기적화료,CysC농도명현승고,여화료전화대조조상비차이유통계학의의(P<0.05),제이주기여제일주기동기상비CysC농도차이유통계학의의(P<0.05).RBP농도명현승고,여화료전화대조조상비차이유통계학의의(P<0.05),단제이주기여제일주기동기상비RNP농도차이무통계학의의(P>0.05).BUN、Crea수평부재화료후제이주기략유승고,여화료전화대조조상비차이유통계학의의(P<0.01);여제일주기동기상비차이유통계학의의(P<0.05).경직선상관성분석현시:CysC화RBP함량변화여eGFR정부상관(P<0.05).결론:여정상대조상비,화료유발조기신손상적환자기혈청CysC화RBP농도명현승고,검측혈청CysC화RBP농도유조우화료유발조기신손상적진단,구유교고적림상응용개치.
@@@@Objective:To evaluate the value of serum CysC and RBP to detect chemotherapy-induced early renal dysfunction in patients with lung cancer.Method:The concentration of surme CysC or RBP were detected in 32 cases of lung cancer chemotherapy by immune turbidimetry at first and second cycle in first course of treatment,simultaneously,the serum creatinine and blood urea nitrogen were determined and 100 healthy subjects were enrolled as control group.Result:After two cycles of chemotherapy,the concentrations of CysC were obviously higher than before chemotherapy and control group(P<0.05). The second cycle compared with the first cycle,the concentrations of CysC were significantly different(P<0.05).the concentrations of RBP were obviously increased,the difference between before chemotherapy and control group were significant(P<0.05).The second cycle compared with the first cycle,the concentrations of RBP were not significantly different(P>0.05).The levels of BUN and Crea were only slightly higher after the second cycle of chemotherapy,the difference between before chemotherapy and control group were significant difference(P<0.01);Compared with the first cycle,there were significant difference(P<0.05). The correlation analysis showed that GFR was negatively correlated with CysC and RBP(P<0.05). Conclusion:Compared with normal controls,the patients with chemotherapy-induced early renal dysfunction had significant increase in serum level of CysC and RBP. Therefore,through measuring the concentrations of serum CysC and RBP had a higher value to early diagnosis chemotherapy-induced renal injury