CAJ | 학술논문

目的:探讨阿立哌唑辅助氟伏沙明治疗强迫障碍的临床疗效及安全性.方法:将54例强迫障碍患者随机分为两组(各27例):阿立哌唑(2.5~10 mg/d)辅助氟伏沙明(250~300 mg/d)组(研究组)、氟伏沙明(250~300 mg/d)组(对照组),治疗观察期均为8周.两组患者于基线及治疗2、4、6、8周末分别评定Yale-Brown强迫量表(Y-BOCS),并采用副反应量表(TESS)评定治疗期间的不良反应.结果:研究组、对照组分别脱落1例、2例.研究组的强迫思维和强迫行为评分在基线及2、4、6、8周末时点间比较差异均有统计学意义(P<0.05);2周末时,两组间的强迫思维评分比较差异有统计学意义(P<0.05),而强迫行为评分比较差异无统计学意义(P>0.05);4周末时,两组间的强迫行为评分比较差异有统计学意义(P<0.05);8周末时,两组间强迫症状有效率比较差异有统计学意义(P<0.05),而不良反应发生率比较差异均无统计学意义(P>0.05).结论:阿立哌唑辅助氟伏沙明可有效、持续地改善强迫障碍患者的强迫症状,且不良反应发生率与单一氟伏沙明治疗相当.
목적:탐토아립고서보조불복사명치료강박장애적림상료효급안전성.방법:장54례강박장애환자수궤분위량조(각27례):아립고서(2.5~10 mg/d)보조불복사명(250~300 mg/d)조(연구조)、불복사명(250~300 mg/d)조(대조조),치료관찰기균위8주.량조환자우기선급치료2、4、6、8주말분별평정Yale-Brown강박량표(Y-BOCS),병채용부반응량표(TESS)평정치료기간적불량반응.결과:연구조、대조조분별탈락1례、2례.연구조적강박사유화강박행위평분재기선급2、4、6、8주말시점간비교차이균유통계학의의(P<0.05);2주말시,량조간적강박사유평분비교차이유통계학의의(P<0.05),이강박행위평분비교차이무통계학의의(P>0.05);4주말시,량조간적강박행위평분비교차이유통계학의의(P<0.05);8주말시,량조간강박증상유효솔비교차이유통계학의의(P<0.05),이불량반응발생솔비교차이균무통계학의의(P>0.05).결론:아립고서보조불복사명가유효、지속지개선강박장애환자적강박증상,차불량반응발생솔여단일불복사명치료상당.
@@@@Objective:To explore the efficacy and safety of fluvoxamine and aripiprazole as adjunctive therapy in the treatment of obsessive-compulsive disorders patients.Method:Total 54 obsessive-compulsive disorders patients were randomly divided into two groups:Fluvoxamine(250-300 mg/d)auxiliaried by aripiprazole(2.5-10 mg/d)group(study group)and fluvoxamine(250-300 mg/d)group(contral group),27 for each. Each group had a 8-week treatment.The efficacy were assessed and analyzed by Yale-Brown Obsessive Compulsive Scale(Y-BOCS) at baseline and at week 2,4,6 and 8. The side effects were assessed by Treatment Emergent Syptom Scale(TESS)during the treatment. Result:Study group and contral group had 1,2 case being off respectively. The obsession and compulsion scores of study group had all statistical difference at baseline and week 2,4 ,6,8 each other(P<0.05). At week 2,in both groups,the obsession scores had statistical difference(P<0.05),while the compulsion scores had no statistical difference(P>0.05). At week 4,in both groups,the compulsion scores had statistical difference(P<0.05). At week 8,the efficient of compulsive symptoms scores of two groups had statistical difference(P<0.05),while the rates of side effects had all no statistical difference (P>0.05). Conclusion:Fluvoxamine and aripiprazole as adjunctive therapy can effectively continue to improve the compulsive symptoms in the treatment of obsessive-compulsive disorders patients,the rate of side effects is similar to that of simple fluvoxamine therapy.