CAJ | 학술논문

目的:研究探讨惠迪粒对溃疡性结肠炎患者的治疗效果及血清白介素(IL-6)和肿瘤坏死因子(TNF-α)的影响.方法:随机选取在本院确诊为溃疡性结肠炎的患者150例,随机平均分为两组,研究组(75例)采用惠迪粒(美沙拉嗪缓释颗粒)治疗;对照组(75例)采用柳氮磺胺吡啶(SASP)治疗,观察比较两组的临床效果及治疗前后血清IL-6、TNF-α的变化情况.结果:研究组治疗效果明显优于对照组,差异有统计学意义(P<0.05);两组患者治疗后的IL-6、TNF-α水平较治疗前明显降低(P<0.05);并且研究组患者IL-6、TNF-α水平降低程度比对照组更加明显,差异有统计学意义(P<0.05).结论:惠迪粒治疗溃疡性结肠炎具有良好临床疗效,考虑可能是通过降低血清中IL-6、TNF-α水平而起作用的,其具体机制尚有待进一步研究完善.
목적:연구탐토혜적립대궤양성결장염환자적치료효과급혈청백개소(IL-6)화종류배사인자(TNF-α)적영향.방법:수궤선취재본원학진위궤양성결장염적환자150례,수궤평균분위량조,연구조(75례)채용혜적립(미사랍진완석과립)치료;대조조(75례)채용류담광알필정(SASP)치료,관찰비교량조적림상효과급치료전후혈청IL-6、TNF-α적변화정황.결과:연구조치료효과명현우우대조조,차이유통계학의의(P<0.05);량조환자치료후적IL-6、TNF-α수평교치료전명현강저(P<0.05);병차연구조환자IL-6、TNF-α수평강저정도비대조조경가명현,차이유통계학의의(P<0.05).결론:혜적립치료궤양성결장염구유량호림상료효,고필가능시통과강저혈청중IL-6、TNF-α수평이기작용적,기구체궤제상유대진일보연구완선.
@@@@Objective:To study the influence of the Huidi grain’s effect on the treatment of patients with ulcerative colitis and serum interleukin (IL-6),tumor necrosis factor(TNF-α). Method:We randomly selected 150 patients in our hospital diagnosed with ulcerative colitis and randomly divided into two groups,the study group(75 cases)adopt the Huidi grain(mesalazine slow-release granules)treatment;the control group(75 cases ) adopt sulfasalazine(SASP)therapy clinical ,observe and compare the two sets of clinical effect and the changes of serum IL-6,TNF-αof before and after treatment. Result:The therapeutic effect of the study group was significantly better than the control group,the difference was statistically significant (P<0.05);After treatment,IL-6,TNF-αlevels are reduced than before significantly(P<0.05);Study group patients with IL-6,TNF-αlevels decreased more significantly than the control group,the difference was statistically significant(P<0.05). Conclusion:The Huidi grain treatment of ulcerative colitis has good clinical efficacy,considering the possibility of works by lowering the serum level of IL-6,TNF-α,the exact mechanism remains to be further study and improve.