CAJ | 학술논문

免疫和炎症反应是缺血性卒中病理过程的重要组成部分,自然免疫和适应性免疫都参与这一过程.免疫反应不仅仅造成炎性损伤,引起外周血和免疫器官出现相应的免疫调节,还在缺血性脑损伤后的脑组织修复和重建中发挥重要作用.抑制缺血诱导的炎症反应和进行免疫调节具有脑保护和脑组织修复/重建作用,可能是缺血性脑损伤的一种新的治疗途径.目前关于缺血性脑损伤的免疫治疗还存在诸多问题,需要深入了解免疫系统功能和脑缺血损伤之间的相互作用,以确保免疫治疗的可行性、有效性和安全性.
면역화염증반응시결혈성졸중병리과정적중요조성부분,자연면역화괄응성면역도삼여저일과정.면역반응불부부조성염성손상,인기외주혈화면역기관출현상응적면역조절,환재결혈성뇌손상후적뇌조직수복화중건중발휘중요작용.억제결혈유도적염증반응화진행면역조절구유뇌보호화뇌조직수복/중건작용,가능시결혈성뇌손상적일충신적치료도경.목전관우결혈성뇌손상적면역치료환존재제다문제,수요심입료해면역계통공능화뇌결혈손상지간적상호작용,이학보면역치료적가행성、유효성화안전성.
Immunity, including innate and adaptive immunity, and inflammation response are important pathological process during ischemic stroke. This process not only leads to inflammatory damages and corresponding modulations in the peripheral blood and immune organs, but also plays a crucial role in the brain tissue repair and reconstruction. Suppression of inflammation and immunomodulation exert remarkable neuroprotection, providing a novel approach for the treatment of ischemic brain injury. However, there are many problems in immune therapy for the ischemic brain injury. The interaction between immune system and ischemic brain injury needs to be further studied to ensure the efficacy and safety of immunotherapy.