CAJ | 학술논문

为了系统研究中国南海软海绵属海绵 Halichondria sp.的化学成分,文章采用多种色谱方法分离纯化,从其氯仿萃取部位中分离得到了9个甾体类化合物,依据理化性质、波谱数据和文献对照的方法鉴定其结构.其结构分别鉴定为:1)3β-羟基-5,8,22-麦角甾三烯-7-酮;2)3β,5α-二羟基-7,22-麦角甾二烯-6-酮;3)3β,5α,6β-胆甾三醇;4)3β,5α,9α-三羟基-7,22-胆甾二烯-6-酮;5)3β-羟基-5-胆甾烯-6-酮;6)5α,8α-环二氧-6,22-麦角甾二烯-3β-醇;7)5α,8α-环二氧-6-胆甾烯-3β-醇;8)7,22-麦角甾二烯-3β,5α,3β-三醇;9)胆甾醇.本研究结果不仅丰富了软海绵属海绵的化学成分研究,而且将为软海绵属海绵的化学分类及甾体类化合物的进一步研究提供有利的理论依据.
위료계통연구중국남해연해면속해면 Halichondria sp.적화학성분,문장채용다충색보방법분리순화,종기록방췌취부위중분리득도료9개치체류화합물,의거이화성질、파보수거화문헌대조적방법감정기결구.기결구분별감정위:1)3β-간기-5,8,22-맥각치삼희-7-동;2)3β,5α-이간기-7,22-맥각치이희-6-동;3)3β,5α,6β-담치삼순;4)3β,5α,9α-삼간기-7,22-담치이희-6-동;5)3β-간기-5-담치희-6-동;6)5α,8α-배이양-6,22-맥각치이희-3β-순;7)5α,8α-배이양-6-담치희-3β-순;8)7,22-맥각치이희-3β,5α,3β-삼순;9)담치순.본연구결과불부봉부료연해면속해면적화학성분연구,이차장위연해면속해면적화학분류급치체류화합물적진일보연구제공유리적이론의거.
@@@@In order to study the chemical constituents of the sponge Halichondria sp. collected from the South China Sea, nine steroids were isolated from the CHCl3 extracts of a South China Sea sponge Halichondria sp. by a variety of chromatographic methods. On the basis of physicochemical properties and detailed spectroscopic analysis and comparison with the data reported in the literature, their structures were identified as 1) 3β-hydroxy-ergosta-5, 8, 22-trien-7-one; 2) 3β, 5α-dihydroxy-ergosta-7, 22-dien-7-one; 3) cholestan-3β, 5α, 6β-triol; 4) 3β, 5α, 9α-trihydroxycholesta-7, 22-dien-6-one; 5) 3β-hydroxy-cholestan-5-en-6-one; 6) 5α, 8α-epidioxy-ergosta-6, 22-dien-3β-ol; 7) 5α, 8α-epidioxy-cholest-6–en -3β-ol; 8) ergosta-7, 22-dien-3β,5α, 3β-triol;and 9) cholesterol, respectively. The results of this study not only enriched the chemical constituents of the sponge of Halichondria, but also provide favorable theoretical basis for its chemical classification and further study of the steroidal compounds.