CAJ | 학술논문

Merlin蛋白是NF2基因的产物,它的缺失可以诱发神经鞘瘤、脑膜瘤、室管膜瘤等一系列肿瘤的发生,而且Merlin蛋白在调控细胞的运动、增殖等方面起着重要作用.本文就Merlin蛋白与膜蛋白、Hippo通路和CD44的相互作用机制以及其在调控细胞侵袭和迁移、酪氨酸蛋白激酶受体等方面进行综述,并且对其未来研究方向进行展望.
Merlin단백시NF2기인적산물,타적결실가이유발신경초류、뇌막류、실관막류등일계렬종류적발생,이차Merlin단백재조공세포적운동、증식등방면기착중요작용.본문취Merlin단백여막단백、Hippo통로화CD44적상호작용궤제이급기재조공세포침습화천이、락안산단백격매수체등방면진행종술,병차대기미래연구방향진행전망.
@@@@Merlin is the product of NF2 gene, of which mutations and deletions are characterized by the development of schwannomas, meningiomas, and ependymomas. Furthermore it serves as a key regulator of several important signaling pathways that regulate cell motility, proliferation, and survival. This article reviews the interactions between merlin and membrane protein, hippo pathway as well as CD44.Meanwhile we summarize the role of merlin in the regulation of invasion and motility as well as receptor tyrosine kinases (RTKS).Some effects ,which are needed to improved, are suggested in this review.