医药前沿
醫藥前沿
의약전연
YIAYAO QIANYAN
2013年
8期
84-85
,共2页
目的:探讨血清胱抑素C(Cyst C)在预测过敏性紫癜患儿肾脏早期损伤的作用.方法:选择2011年2月至2012年9月我院尿常规正常的 HSP 住院患儿102例(HSP组),其中男63例、女39例,平均年龄7.59±2.83岁.选择50名健康体检儿童作为对照组,其中男27名、女23名,平均年龄8.18±2.85岁.对所有研究对象测定血清 CysC 浓度、血尿素氮(blood urea nitrogen,BUN)浓度、血清肌酐(serum creatinine,SCr)浓度、内生肌酐清除率(Creatinine Clearance rate,CCr)(mL/min),患者入院时测定晨起空腹尿常规.结果:在发病4天对有肾脏早期损伤HSP组内血清胱抑素C增高,而且与对照组比较血清CysC差异有统计学意义(t=3.18, P <0.05),血清 BUN(t=0.53)、Cr(t=0.84)、CCr(t=1.86)差异无统计学意义(P 均>0.05).发病8天后 HSP 组与对照组比较,有肾脏损伤的患者血清 CysC 也明显增高,差异有统计学意义(t=4.18,P <0.05),血清 BUN(t=4.53)、Cr(t=3.65)、CCr(t=4.75)差异有统计学意义(P 均<0.05).结论:血清胱抑素 C 是一种稳定可靠的预测肾早期损害的指标.
目的:探討血清胱抑素C(Cyst C)在預測過敏性紫癜患兒腎髒早期損傷的作用.方法:選擇2011年2月至2012年9月我院尿常規正常的 HSP 住院患兒102例(HSP組),其中男63例、女39例,平均年齡7.59±2.83歲.選擇50名健康體檢兒童作為對照組,其中男27名、女23名,平均年齡8.18±2.85歲.對所有研究對象測定血清 CysC 濃度、血尿素氮(blood urea nitrogen,BUN)濃度、血清肌酐(serum creatinine,SCr)濃度、內生肌酐清除率(Creatinine Clearance rate,CCr)(mL/min),患者入院時測定晨起空腹尿常規.結果:在髮病4天對有腎髒早期損傷HSP組內血清胱抑素C增高,而且與對照組比較血清CysC差異有統計學意義(t=3.18, P <0.05),血清 BUN(t=0.53)、Cr(t=0.84)、CCr(t=1.86)差異無統計學意義(P 均>0.05).髮病8天後 HSP 組與對照組比較,有腎髒損傷的患者血清 CysC 也明顯增高,差異有統計學意義(t=4.18,P <0.05),血清 BUN(t=4.53)、Cr(t=3.65)、CCr(t=4.75)差異有統計學意義(P 均<0.05).結論:血清胱抑素 C 是一種穩定可靠的預測腎早期損害的指標.
목적:탐토혈청광억소C(Cyst C)재예측과민성자전환인신장조기손상적작용.방법:선택2011년2월지2012년9월아원뇨상규정상적 HSP 주원환인102례(HSP조),기중남63례、녀39례,평균년령7.59±2.83세.선택50명건강체검인동작위대조조,기중남27명、녀23명,평균년령8.18±2.85세.대소유연구대상측정혈청 CysC 농도、혈뇨소담(blood urea nitrogen,BUN)농도、혈청기항(serum creatinine,SCr)농도、내생기항청제솔(Creatinine Clearance rate,CCr)(mL/min),환자입원시측정신기공복뇨상규.결과:재발병4천대유신장조기손상HSP조내혈청광억소C증고,이차여대조조비교혈청CysC차이유통계학의의(t=3.18, P <0.05),혈청 BUN(t=0.53)、Cr(t=0.84)、CCr(t=1.86)차이무통계학의의(P 균>0.05).발병8천후 HSP 조여대조조비교,유신장손상적환자혈청 CysC 야명현증고,차이유통계학의의(t=4.18,P <0.05),혈청 BUN(t=4.53)、Cr(t=3.65)、CCr(t=4.75)차이유통계학의의(P 균<0.05).결론:혈청광억소 C 시일충은정가고적예측신조기손해적지표.
Objective: To investigate the serum cystatin C (Cyst C) in the prediction of early renal damage in children with Henoch-Schonlein purpura role. Method: Select 102 hospitalized patients (HSP group), male 63 cases, female 39 cases, mean age 7.59± 2.83 years old. Select 50 healthy children as control group, male 27, female 23, mean age 8.18± 2.85 years old. For al the research object of serum CysC concentration, blood urea nitrogen ( blood urea nitrogen, BUN, serum creatinine ( serum ) concentration, creatinine concentration, SCr ), Creatinine Clearance rate. Determination of fasting urine routine to patients on admission. Results: Compared with the control group, In 4 days, on early renal damage in the HSP group, serum cystatin C increase and with significant difference (t=3.18,P<0.05), serum BUN (t=0.53), Cr (t=0.84), CCr (t=1.86) showed no significant difference (P>0.05). Compared with the control group ,after 8 days of onset, renal injury in serum of patients with CysC were significantly higher in HSP group, with significant difference (t=4.18,P<0.05), serum BUN (t=4.53), Cr (t=3.65), CCr (t=4.75) with significant difference (P<0.05). Conclusion: serum cystatin C is a reliable prediction of early renal damage with Henoch-Schonlein purpura role.
