中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2013年
12期
155-158
,共4页
Smad蛋白%TGFβs%磷酸化
Smad蛋白%TGFβs%燐痠化
Smad단백%TGFβs%린산화
Smad proteins%TGFβs%Phosphorylation
Smad蛋白家族是转化生长因子β(TGFβs)超家族重要的细胞因子,共同担负着调节细胞生长、分化、凋亡等过程,主要由8种不同的蛋白构成整个Smad家族,通过可逆磷酸化对多种信号传导通路的功能起着关键的调节作用,分别行使兴奋和抑制等不同作用.本文对Smad蛋白调节作用机制进行综述.
Smad蛋白傢族是轉化生長因子β(TGFβs)超傢族重要的細胞因子,共同擔負著調節細胞生長、分化、凋亡等過程,主要由8種不同的蛋白構成整箇Smad傢族,通過可逆燐痠化對多種信號傳導通路的功能起著關鍵的調節作用,分彆行使興奮和抑製等不同作用.本文對Smad蛋白調節作用機製進行綜述.
Smad단백가족시전화생장인자β(TGFβs)초가족중요적세포인자,공동담부착조절세포생장、분화、조망등과정,주요유8충불동적단백구성정개Smad가족,통과가역린산화대다충신호전도통로적공능기착관건적조절작용,분별행사흥강화억제등불동작용.본문대Smad단백조절작용궤제진행종술.
The Smad family of proteins is important mediators of the transforming growth factor-beta(TGFβs)family of cytokines,jointly charges with the regulation of cell growth,differentiation,and apoptosis process. It is mainly constituted by eight different proteins and plays a key role in regulating the function of a variety of signal transduction pathways through reversible phosphorylation,exercising excitatory and inhibitory effects. This review discusses Smad protein regulating mechanism.
