CAJ | 학술논문

目的:应用液基细胞学联合HPV分型方法检测妊娠合并宫颈上皮内瘤变(Cervical intraepithelial neoplasia,CIN),初步了解此类患者中TCT及HPV感染情况与妊娠宫颈病变的关系.方法:对象为2006年1月至2012年1月确诊为妊娠合并宫颈上皮内瘤变的72例患者,初次孕期保健均进行细胞学、HPV检测,对这些临床资料进行回顾性分析研究.结果:妊娠合并CIN发生率为2.1%.72例患者中全部产前行宫颈TCT检测,HSIL为32例,LSIL为40例,56例于产前保健时检测HPV,其中48例(85.7%)为阳性结果,32例为HPV16型单独或混合感染.72例孕期保健时行阴道镜活检病理诊断CINⅠ16例、CINⅡ16例、CINⅢ40例.结论:液基细胞学联合HPV分型检测在妊娠合并宫颈上皮内瘤变患者的应用是安全而且有效的.在妊娠期CIN患者中HPV感染率高,且HPV16型与CIN高等级病变关系密切.
목적:응용액기세포학연합HPV분형방법검측임신합병궁경상피내류변(Cervical intraepithelial neoplasia,CIN),초보료해차류환자중TCT급HPV감염정황여임신궁경병변적관계.방법:대상위2006년1월지2012년1월학진위임신합병궁경상피내류변적72례환자,초차잉기보건균진행세포학、HPV검측,대저사림상자료진행회고성분석연구.결과:임신합병CIN발생솔위2.1%.72례환자중전부산전행궁경TCT검측,HSIL위32례,LSIL위40례,56례우산전보건시검측HPV,기중48례(85.7%)위양성결과,32례위HPV16형단독혹혼합감염.72례잉기보건시행음도경활검병리진단CINⅠ16례、CINⅡ16례、CINⅢ40례.결론:액기세포학연합HPV분형검측재임신합병궁경상피내류변환자적응용시안전이차유효적.재임신기CIN환자중HPV감염솔고,차HPV16형여CIN고등급병변관계밀절.
@@@@Objective: The present study aimed to investigate the relationship between cervical intraepithelial neoplasia (CIN) and human papilloma virus (HPV) infection during pregnancy using liquid-based cytology and HPV test. Methods: We prospectively studied the clinical data of 72 pregnant women with CIN who were hospitalized between January 2006 and January 2012 at Tangshan Gongren Hospital. All patients underwent liquid-based thin-layer cytology technique and/or HPV test. Results: Thirty two cases, which included 16 cases each of CIN Ⅰ and Ⅱ, displayed high-grade squamous intraepithelial lesion. The other 40 cases were CIN Ⅲcharacterized by low-grade squamous intraepithelial lesion based on biopsy pathology through colposcopy. A total of 48 (85.7% ) HPV-positive cases were determined among 56 antenatal patients. Moreover, 32 of the 48 HPV-positive cases had either HPV16 infection alone or a mixture of different infection types. Conclusion: Results indicated that the CIN pregnant patients exhibited high frequency of HPV infections, and its HPV16 type is closely associated with the pathological development of high-grade lesions.