CAJ | 학술논문

目的:探讨术前紫杉醇联合奈达铂化疗对ⅠB2~ⅡB期宫颈癌的近期疗效.方法:选择2008年3月~2011年3月期间收治的局部晚期宫颈癌患者58例,分为研究组和对照组,两组患者经病理确诊后,研究组给予紫杉醇联合奈达铂的化疗方案并行全麻下广泛全子宫切除和盆腔淋巴结清扫术,而对照组则在未化疗的情况下直接进行手术,并对两组患者的临床疗效进行比较分析.结果:研究组31例患者有效率为80.6%,病理检查提示淋巴结阳性率、阴道切缘阳性率、宫旁累及率、脉管浸润率均较对照组低,有显著性差异(P<0.05).结论:紫杉醇联合奈达铂方案对宫颈癌患者进行新辅助化疗,可缩小肿瘤体积,降低肿瘤临床分期,提高手术率.
목적:탐토술전자삼순연합내체박화료대ⅠB2~ⅡB기궁경암적근기료효.방법:선택2008년3월~2011년3월기간수치적국부만기궁경암환자58례,분위연구조화대조조,량조환자경병리학진후,연구조급여자삼순연합내체박적화료방안병행전마하엄범전자궁절제화분강림파결청소술,이대조조칙재미화료적정황하직접진행수술,병대량조환자적림상료효진행비교분석.결과:연구조31례환자유효솔위80.6%,병리검사제시림파결양성솔、음도절연양성솔、궁방루급솔、맥관침윤솔균교대조조저,유현저성차이(P<0.05).결론:자삼순연합내체박방안대궁경암환자진행신보조화료,가축소종류체적,강저종류림상분기,제고수술솔.
@@@@Objective: To investigate the efficiency of paclitaxel combined with nadaplatin in locally advanced cervical cancer be-fore operation. Methods: A total of 58 patients with locally advanced cervical cancer in our hospital from March 2008 to March 2011 were divided into the study group and the control group. After the definite diagnosis of the patients, the observation group received pacl-itaxel and nadaplatin chemotherapy concurrent with anesthesia-extensive hysterectomy and pelvic lymph node dissection. The control group underwent surgery directly without chemotherapy. The clinical efficacy in the two groups was analyzed and compared. Results:The combination of paclitaxel and nadaplatin can achieve an 80.6% effective therapeutic rate. All patients can then be treated by sur-gery. The rate of lymphatic vascular space invasion was lower in the study group (i.e., paclitaxel combined with nadaplatin group). Con-clusion: Stage ⅠB2 to ⅡB bulky cervical cancer can be treated by combined chemotherapy of paclitaxel combined with nadaplatin method before operation. The success rate of operation can be increased.