中国肿瘤临床
中國腫瘤臨床
중국종류림상
CHINESE JOURNAL OF CLINICAL ONCOLOGY
2013年
7期
423-426
,共4页
超小超顺磁性氧化铁粒子%磁共振成像%分子影像学%靶向载体%聚合物
超小超順磁性氧化鐵粒子%磁共振成像%分子影像學%靶嚮載體%聚閤物
초소초순자성양화철입자%자공진성상%분자영상학%파향재체%취합물
ultra-small superparamagnetic iron oxide%magnetic resonance imaging%molecular imaging%targeting carrier%polymer
超小超顺磁性氧化铁粒子(Ultrasmall superparamagnetic iron oxid,USPIO)作为MRI阴性显影剂因其较高的空间分辨率及低毒性近年来已逐渐投入临床使用.结合迅猛发展的分子影像学、高分子聚合物技术,各种肿瘤靶向MRI显影剂受到广泛且深入的研究;USPIO结合不同肿瘤特异性的受体在肿瘤的早期诊断及疗效预测、肿瘤干细胞示踪等方面相比传统的钆螯合物MRI显影剂表现出巨大的潜力及优势.
超小超順磁性氧化鐵粒子(Ultrasmall superparamagnetic iron oxid,USPIO)作為MRI陰性顯影劑因其較高的空間分辨率及低毒性近年來已逐漸投入臨床使用.結閤迅猛髮展的分子影像學、高分子聚閤物技術,各種腫瘤靶嚮MRI顯影劑受到廣汎且深入的研究;USPIO結閤不同腫瘤特異性的受體在腫瘤的早期診斷及療效預測、腫瘤榦細胞示蹤等方麵相比傳統的釓螯閤物MRI顯影劑錶現齣巨大的潛力及優勢.
초소초순자성양화철입자(Ultrasmall superparamagnetic iron oxid,USPIO)작위MRI음성현영제인기교고적공간분변솔급저독성근년래이축점투입림상사용.결합신맹발전적분자영상학、고분자취합물기술,각충종류파향MRI현영제수도엄범차심입적연구;USPIO결합불동종류특이성적수체재종류적조기진단급료효예측、종류간세포시종등방면상비전통적구오합물MRI현영제표현출거대적잠력급우세.
@@@@Ultra-small superparamagnetic iron oxide (USPIO) particles have been clinically applied in MRI negative contrast in recent years because of the particles high spatial resolution and low toxicity. With the rapid development of molecular imaging and poly-mer technology, numerous kinds of tumor-targeted MRI negative contrast have been investigated comprehensively. Combining USPIO with different tumor-targeting carriers in the early diagnosis of cancer, assessing the therapeutic effect, and tracing cancer stem cells have great potential and advantages compared with traditional gadolinium chelates MRI contrast.
