CAJ | 학술논문

目的探讨神经节苷脂治疗新生儿缺氧缺血性脑病(HIE)的临床疗效.方法选取HIE患儿80例,随机分为观察组和对照组,各40例.两组患儿均给予常规及对症支持治疗,观察组加用神经节苷脂,对照组加用胞二磷胆碱.观察临床治疗效果.结果观察组患儿总有效率92.50%,明显高于对照组的75.00%(P<0.05).治疗2周和4周后,两组患者NBNA评分较治疗前均提高(P<0.05),观察组提高更显著(P<0.05).结论在常规治疗基础上加用神经节苷脂治疗中重度HIE,可以显著改善患儿临床症状,促进受损神经功能恢复,提高疗效.
목적탐토신경절감지치료신생인결양결혈성뇌병(HIE)적림상료효.방법선취HIE환인80례,수궤분위관찰조화대조조,각40례.량조환인균급여상규급대증지지치료,관찰조가용신경절감지,대조조가용포이린담감.관찰림상치료효과.결과관찰조환인총유효솔92.50%,명현고우대조조적75.00%(P<0.05).치료2주화4주후,량조환자NBNA평분교치료전균제고(P<0.05),관찰조제고경현저(P<0.05).결론재상규치료기출상가용신경절감지치료중중도HIE,가이현저개선환인림상증상,촉진수손신경공능회복,제고료효.
Objective To investigate the clinical therapeutic effects of ganglioside on hypoxic-ischemic encephalopathy (HIE). Methods 80 sick children meeting the criteria were selected and randomly divided into observation group and control group,40 children each group; based on routine,symptomatic and supporting treatments;the observation group was supplemented with ganglioside,while the control group supplemented with cytidine diphosphate choline,and the clinical therapeutic effects were observed. Results The total effective rate of the observation group was 92.50%,significantly higher than that of the control group(75.00%),and the difference was statistically significant(P<0.05). The difference in pretherapy NBNA score between the two groups had no statistic significance(P>0.05);in 2 weeks and 4 weeks after the treatments,the NBNA scores of both groups were higher than those before the treatments(P<0.05),but the NBNA scores of the observation group were increased more significantly(P<0.05). Conclusion Routine treatment supplemented with ganglioside in treatment of moderate and severe HIE can significantly improve the clinical symptoms,promote recovery of damaged nerve functions and elevate clinical therapeutic effects,and consequently is worthy of clinical generalization and application.