CAJ | 학술논문

目的探讨慢性舒张性心力衰竭患者动脉僵硬度的影响因素.方法选取慢性舒张性心力衰竭患者354例,测量身高、体重、血压,计算BMI,采集空腹静脉血分析血脂、血糖、血浆B型脑钠肽(BNP)等指标,超声心动图检查各项指标,采用动脉硬化检测仪测量CAVI,分析CAVI与各临床特征的相关性.结果单因素相关分析结果显示,CAVI与年龄、收缩压、BNP呈明显正相关(r=0.3664、0.1193、0.2591,P<0.05或0.01),与BMI、E/A呈显著负相关(r=0.2040、0.1759,均P<0.01);多元逐步回归分析显示,高龄、女性、吸烟史、BMI、BNP、E/A是CAVI的独立影响因素(β=0.0443、0.2617、-0.0675、0.3904、0.4939、-0.7899,P<0.05或0.01),且E/A比值作用最强(P<0.05).结论老龄、女性、吸烟、BMI、BNP、E/A是影响慢性舒张性心力衰竭患者动脉僵硬度的主要危险因素.
목적탐토만성서장성심력쇠갈환자동맥강경도적영향인소.방법선취만성서장성심력쇠갈환자354례,측량신고、체중、혈압,계산BMI,채집공복정맥혈분석혈지、혈당、혈장B형뇌납태(BNP)등지표,초성심동도검사각항지표,채용동맥경화검측의측량CAVI,분석CAVI여각림상특정적상관성.결과단인소상관분석결과현시,CAVI여년령、수축압、BNP정명현정상관(r=0.3664、0.1193、0.2591,P<0.05혹0.01),여BMI、E/A정현저부상관(r=0.2040、0.1759,균P<0.01);다원축보회귀분석현시,고령、녀성、흡연사、BMI、BNP、E/A시CAVI적독립영향인소(β=0.0443、0.2617、-0.0675、0.3904、0.4939、-0.7899,P<0.05혹0.01),차E/A비치작용최강(P<0.05).결론노령、녀성、흡연、BMI、BNP、E/A시영향만성서장성심력쇠갈환자동맥강경도적주요위험인소.
@@@@Objective To investigate the factors affecting arterial stiffness in patients with chronic diastolic heart failure. Methods Three hundred and fifty four patients with chronic diastolic heart failure were enrol ed in the study. The height, weight, blood pressure was measured, and body mass index calculated. Fasting blood lipids, blood glucose, plasma B-type natriuretic peptide (BNP) and other indicators were measured. Echocardiography and Cardio-Ankle Vascular Index (CAVI) was evaluated. The correlation of CAVI and other clinical parameters was analyzed. Results The univariance analysis showed that CAVI was positively correlated with age (r=0.3664, P<0.01), systolic blood pressure (r=0.1193, P<0.05), and BNP (r=0.2591, P<0.01), and negatively correlated with body mass index (r=-0.2040, P<0.01) and E/A ratio (r=-0.1759, P<0.01). Stepwise multiple re-gression analysis showed that age, sex, smoking history, body mass index, BNP and E/A ratio were the independent risk factors of CAVI (β=0.0443, 0.2617,-0.0675, 0.3904, 0.4939,-0.7899;P<0.05 or 0.01), and the E/A ratio was the strongest influencing factor (P<0.05). Conclusion Aging, female sex, smoking, and body mass index, BNP and E/A ratio are the major risk factors of arterial stiffness in patients with chronic diastolic ventricular failure.