CAJ | 학술논문

目的探讨白介素-27(IL-27)rs153109单核苷酸多态性与免疫性血小板减少症(ITP)发病的相关性.方法采用聚合酶链反应-限制性片段长度多态性技术对100例患者和100例健康对照者进行IL-27 rs153109基因定型.结果整体分析提示ITP患者的IL-27 rs153109基因多态性与发病无相关性.根据年龄将患者分为儿童ITP和成人ITP时,两组与对照组比较,该基因的基因型和等位基因频率均没有统计学差异(均P>0.05).再根据病程,将ITP患者分为急性儿童ITP、慢性儿童ITP、急性成人ITP和慢性成人ITP时,4组分别与对照组比较,该基因的基因型和等位基因频率也均没有统计学差异(均P>0.05).结论 IL-27 rs153109基因多态性在ITP患者和健康对照者中有相似的分布,表明该基因多态性可能与ITP的发病无关.
목적탐토백개소-27(IL-27)rs153109단핵감산다태성여면역성혈소판감소증(ITP)발병적상관성.방법채용취합매련반응-한제성편단장도다태성기술대100례환자화100례건강대조자진행IL-27 rs153109기인정형.결과정체분석제시ITP환자적IL-27 rs153109기인다태성여발병무상관성.근거년령장환자분위인동ITP화성인ITP시,량조여대조조비교,해기인적기인형화등위기인빈솔균몰유통계학차이(균P>0.05).재근거병정,장ITP환자분위급성인동ITP、만성인동ITP、급성성인ITP화만성성인ITP시,4조분별여대조조비교,해기인적기인형화등위기인빈솔야균몰유통계학차이(균P>0.05).결론 IL-27 rs153109기인다태성재ITP환자화건강대조자중유상사적분포,표명해기인다태성가능여ITP적발병무관.
@@@@Objective To investigate the association of single nucleotide polymorphisms (SNP) of interleukin-27 (IL-27) genes with the risk for immune thrombocytopenic purpura (ITP). Methods The genotype of IL-27 rs153109 polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 100 patients with ITP and 100 healthy individuals. Results In ITP patients, the frequencies of GG, GA and AA genotypes, and G and A al eles were 10.0%, 50.0%,40.0% and 35.0%, 65.0%, respectively. There was no significant difference in genotype and al eles distribution between ITP patients and healthy controls (P=0.88 and 0.83, respectively). Similar results were found between the two groups when strati-fied by the age and disease course to subgroups acute adult, chronic adult, acute childhood and chronic childhood. Conclusion IL-27 polymorphism may not be involved in susceptibility to ITP.