CAJ | 학술논문

目的:观察小槐花水提物的药理作用.方法:采用对戊巴比妥钠小鼠睡眠时间的影响实验;小鼠醋酸扭体法;小鼠碳末廓清法和对正常小鼠血清SOD活性和MDA含量的影响实验,以及急性毒性试验.结果:小槐花水提物能明显促进小鼠睡眠并延长其睡眠时间,减少醋酸所致的小鼠扭体反应次数,能提高单核巨噬细胞吞噬指数,降低小鼠血清MDA含量,同时提高SOD活性.小鼠最大给药量为220.5g生药/kg.结论:提示小槐花水提物具有明显的镇静催眠,镇痛,免疫增强和抗氧化作用,且毒性较低.
목적:관찰소괴화수제물적약리작용.방법:채용대무파비타납소서수면시간적영향실험;소서작산뉴체법;소서탄말곽청법화대정상소서혈청SOD활성화MDA함량적영향실험,이급급성독성시험.결과:소괴화수제물능명현촉진소서수면병연장기수면시간,감소작산소치적소서뉴체반응차수,능제고단핵거서세포탄서지수,강저소서혈청MDA함량,동시제고SOD활성.소서최대급약량위220.5g생약/kg.결론:제시소괴화수제물구유명현적진정최면,진통,면역증강화항양화작용,차독성교저.
@@@@ Objective: To observe the pharmacological action of aqueous extract from Desmodium Caudatum. Methods: The experience was made with pentobarbital-induced hypnosis in mice, the rat's body torsion test, the rat carbo clearance method for Serum SOD and MDA in normal mice and acute toxicity test. Results: Aqueous Extract from Desmodium Caudatum can obviously facilitate sleep, extend sleep time, reduce the body torsion induced by acetic acid, enhance the mononuclear macrophage phagocytic index, reduce the blood serum content of MDA and improve the activity of SOD in mice. The maxi-mum dosage was 220.5 g crude drug/kg. Conclusion: Aqueous Extract from Desmodium Caudatum can provide obvious sedative, hypnotic, analgesia, immune enhancement and antioxygenation effects,with low toxicity.