中医药导报
中醫藥導報
중의약도보
GUIDING JOURNAL OF TCM
2013年
4期
80-81
,共2页
糖净宁颗粒%血糖%急性毒性
糖淨寧顆粒%血糖%急性毒性
당정저과립%혈당%급성독성
Tangjingning granules%Blood glucose%Acute toxicity
目的:了解糖净宁颗粒的急性毒性及对高血糖小鼠血糖的影响.方法:给小鼠静脉注射四氧嘧啶复制高血糖模型,观察糖净宁颗粒对高血糖小鼠的影响;测定小鼠灌服给药的急性毒性.结果:糖净宁颗粒高、中剂量组可显著降低四氧嘧啶诱导的高糖血症小鼠血清糖水平,糖净宁颗粒灌服给药的最大给药量为48.62 g药材/kg.结论:糖净宁颗粒具显著的降糖作用,安全性好.
目的:瞭解糖淨寧顆粒的急性毒性及對高血糖小鼠血糖的影響.方法:給小鼠靜脈註射四氧嘧啶複製高血糖模型,觀察糖淨寧顆粒對高血糖小鼠的影響;測定小鼠灌服給藥的急性毒性.結果:糖淨寧顆粒高、中劑量組可顯著降低四氧嘧啶誘導的高糖血癥小鼠血清糖水平,糖淨寧顆粒灌服給藥的最大給藥量為48.62 g藥材/kg.結論:糖淨寧顆粒具顯著的降糖作用,安全性好.
목적:료해당정저과립적급성독성급대고혈당소서혈당적영향.방법:급소서정맥주사사양밀정복제고혈당모형,관찰당정저과립대고혈당소서적영향;측정소서관복급약적급성독성.결과:당정저과립고、중제량조가현저강저사양밀정유도적고당혈증소서혈청당수평,당정저과립관복급약적최대급약량위48.62 g약재/kg.결론:당정저과립구현저적강당작용,안전성호.
@@@@ Objective: To investigate the acute toxicity and hypoglycemic effect of Tangjingning granules in mice. Methods:Diabetes model was established by alloxan in mice and the hypoglycemic effects were investigated after oral administration of Tangjingning granules, and the acute toxicity of Tangjingning granules was detected. Results: Tangjingning granules significantly reduced the leave of serum glucose in diabetic mice, and the maximum dose was 48.62 g/kg for mice in acute toxicity exper-iment. Conclusion: Tangjingning granules has hypoglycemic action, with favorable safety.
