CAJ | 학술논문

目的观察丹参注射液联合依达拉奉预防颅内动脉瘤术后脑血管痉挛的的临床效果及安全性.方法将2012年6月至2013年1月在我院神经内科住院治疗的64例颅内动脉瘤患者随机分成两组,通过显微外科手术夹闭及介入治疗后,对照组接受常规治疗(尼莫地平注射液,长春西汀等),治疗组在常规治疗的基础上使用丹参注射液联合依达拉奉治疗,2周后进行疗效评定.结果两组治疗后7、14天,MCA 的平均流速与治疗前相比均显著降低,(P<0.05);治疗后第7天,治疗组 MCA 的平均流速显著低于对照组(P<0.05);治疗后第14天,两组 MCA 平均流速的差异无统计学意义(P>0.05),脑血管痉挛发生率的差异有统计学意义(P<0.05),脑梗死发生率、死亡率及不良反应发生率的差异均无统计学意义(P>0.05).结论丹参注射液联合依达拉奉预防颅内动脉瘤术后脑血管痉挛的的临床效果显著,副作用小,可以作为预防颅内动脉瘤术后脑血管痉挛的联合方案.
목적관찰단삼주사액연합의체랍봉예방로내동맥류술후뇌혈관경련적적림상효과급안전성.방법장2012년6월지2013년1월재아원신경내과주원치료적64례로내동맥류환자수궤분성량조,통과현미외과수술협폐급개입치료후,대조조접수상규치료(니막지평주사액,장춘서정등),치료조재상규치료적기출상사용단삼주사액연합의체랍봉치료,2주후진행료효평정.결과량조치료후7、14천,MCA 적평균류속여치료전상비균현저강저,(P<0.05);치료후제7천,치료조 MCA 적평균류속현저저우대조조(P<0.05);치료후제14천,량조 MCA 평균류속적차이무통계학의의(P>0.05),뇌혈관경련발생솔적차이유통계학의의(P<0.05),뇌경사발생솔、사망솔급불량반응발생솔적차이균무통계학의의(P>0.05).결론단삼주사액연합의체랍봉예방로내동맥류술후뇌혈관경련적적림상효과현저,부작용소,가이작위예방로내동맥류술후뇌혈관경련적연합방안.
@@@@Objective To explore the clinical effect and safety of salvia miltiorrhiza injection combined with edaravone in the treatment of cerebral vasospasm suffering from intracranial aneurysm. Methods 64 cases accepting treatment from June 2012 to Jan 2013 in our hospital from June 2012 to January 2013 were randomly divided into two groups after surgery and interventional therapy, the control group was treated with conventional therapy which involved Nimodipine Injection, vin-pocetine, etc., and the treatment group was treated with salvia miltiorrhiza injection combined with edaravone based on the conventional therapy. The clinical efficacy was compared after 2 weeks’treatment. Results After 7 days’and 14 days’treat-ment, the mean blood flow velocity of MCA in two groups were both statistically lower than those before treatment (P<0.05), On the 7th day after treatment, the mean blood flow velocity of MCA in treatment group was remarkably lower than that in the control group (P<0.05). On the 14th day after treatment, no significant difference was found in the mean blood flow velocity of MCA, incidence rate of cerebral infarction and adverse reactions, mortality between two groups (P>0.05). The incidence rate of cerebral angiospasm was significantly lower in the treatment group than that in the control group (P<0.05). Conclusion Salvia Miltiorrhiza injection combined with Edaravone was remarkably effective in the prevention of cerebral va-sospasm after intracranial aneurysm surgery, which also had few adverse reactions and could be used as a combination therapy for the cerebral vasospasm after intracranial aneurysm surgery.