CAJ | 학술논문

目的:分析急性颅脑损伤后不同严重程度、不同时间段血清白细胞介素10(IL-10)的含量变化及临床意义.方法:77例急性颅脑损伤患者按入院时GCS评分分为轻度、中度和重度三组,分别于伤后1d、2d、3d、4d、5d抽取静脉血液,采用酶联免疫吸附法(ELISA)测定血清IL-10含量,根据IL-10的动态变化,分析急性颅脑损伤程度与血清IL-10含量之间关系.结果:不同程度的急性颅脑损伤患者血清IL-10含量在伤后高于对照组(P<0.05),而在重型颅脑损伤中增高较轻型和中型损伤更为明显(P<0.05).结论:血清IL-10含量与急性颅脑损伤程度存在相关性,可作为评估急性颅脑损伤严重程度及预后的一个客观指标.
목적:분석급성로뇌손상후불동엄중정도、불동시간단혈청백세포개소10(IL-10)적함량변화급림상의의.방법:77례급성로뇌손상환자안입원시GCS평분분위경도、중도화중도삼조,분별우상후1d、2d、3d、4d、5d추취정맥혈액,채용매련면역흡부법(ELISA)측정혈청IL-10함량,근거IL-10적동태변화,분석급성로뇌손상정도여혈청IL-10함량지간관계.결과:불동정도적급성로뇌손상환자혈청IL-10함량재상후고우대조조(P<0.05),이재중형로뇌손상중증고교경형화중형손상경위명현(P<0.05).결론:혈청IL-10함량여급성로뇌손상정도존재상관성,가작위평고급성로뇌손상엄중정도급예후적일개객관지표.
Objective:Analysis of acute craniocerebral injury of different severity in different time period of serum interleukin 10 (IL-10)content changes and its clinical significance. Methods: 77 cases of patients with acute craniocerebral injury by admission GCS score is divided into mild, moderate and severe group three, respectively, after the injury to 1D, 2D, 3D, 4D,5D venous blood, using enzyme-linked immunosorbent assay (ELISA)method for the determination of the content of serum IL-10, according to the dynamic changes of IL-10, Analyze the relationship between the degree of acute craniocerebral injury and the content of IL-10 in serum. The results of acute brain damage of different degree of serum IL-10 in patients with higher than that of the control group after injury(P<0.05), and increased in severe craniocerebral injury is relatively light and medium damage is more obvious(P<0.05). Correlation between serum IL-10 levels and the degree of conclusion acute craniocerebral injury, can be used as an objective index for assessment of severity and prognosis of acute craniocerebral injury.