CAJ | 학술논문

目的探讨狼疮肾炎(lupus nephritis, LN)患者治疗方案与病理分型的关系.方法选取2006年~2011年期间怀化医专附属怀化市第三人民医院收治的49例系统性红斑狼疮(systemic lupus erythematosus,SLE)伴肾损害的患者,均行肾活检证实为LN.分析病理类型,比较予肾上腺皮质激素(激素)联合免疫抑制剂治疗前后的临床指标.结果肾活检结果分别为Ⅰ型3例、Ⅱ型8例、Ⅲ型6例、Ⅳ型17例、Ⅴ型11例、Ⅵ型4例.对比每组中治疗前后的血尿素氮、血肌酐、血沉、血清C 3、尿蛋白量五项临床指标均有统计学意义(P值分别为0.022,0.031,0.005,0.000,0.014);对比各组之间治疗后的血尿素氮、血肌酐、血沉、血清C 3、尿蛋白量五项临床指标均无统计学意义(P>0.05).结论 LN的病理类型以Ⅳ型和Ⅴ型居多.三组的治疗效果相当,可见激素联合免疫抑制剂对各型LN的治疗效果良好.
목적탐토랑창신염(lupus nephritis, LN)환자치료방안여병리분형적관계.방법선취2006년~2011년기간부화의전부속부화시제삼인민의원수치적49례계통성홍반랑창(systemic lupus erythematosus,SLE)반신손해적환자,균행신활검증실위LN.분석병리류형,비교여신상선피질격소(격소)연합면역억제제치료전후적림상지표.결과신활검결과분별위Ⅰ형3례、Ⅱ형8례、Ⅲ형6례、Ⅳ형17례、Ⅴ형11례、Ⅵ형4례.대비매조중치료전후적혈뇨소담、혈기항、혈침、혈청C 3、뇨단백량오항림상지표균유통계학의의(P치분별위0.022,0.031,0.005,0.000,0.014);대비각조지간치료후적혈뇨소담、혈기항、혈침、혈청C 3、뇨단백량오항림상지표균무통계학의의(P>0.05).결론 LN적병리류형이Ⅳ형화Ⅴ형거다.삼조적치료효과상당,가견격소연합면역억제제대각형LN적치료효과량호.
Objective To investigate the relationship between therapy and pathological type of lupus nephritis patients. Methods Totally 49 SLE patients with renal damage in our hospital from 2006 to 2011 were selected. All were proven LN after renal biopsy. Analyze the pathological type and the change of clinical indicators after the treatment of adrenal cortical hormone combined with Immunosuppressant. Results There were 3 cases of