分子诊断与治疗杂志
分子診斷與治療雜誌
분자진단여치료잡지
JOURNAL OF MOLECULAR DIAGNOSIS AND THERAPY
2013年
2期
128-133
,共6页
内质网氨基肽酶 1%I型主要组织相容性抗原复合物%免疫反应%抗原加工
內質網氨基肽酶 1%I型主要組織相容性抗原複閤物%免疫反應%抗原加工
내질망안기태매 1%I형주요조직상용성항원복합물%면역반응%항원가공
Endoplasmic reticulum aminopeptidase 1%Major histocompatibility complex class I%Immune response%Antigen progressing
内质网氨基肽酶1(endoplasmic reticulum aminopeptidase 1,ERAP1)是氨基肽酶 M1家族中的一个多功能的酶,在血压调节、血管发生、细胞因子受体的胞外区脱落,以及对递呈至 I 型主要组织相容性抗原复合物(major histocompatibility complex class I,MHC I)的抗原肽的加工中发挥作用.ERAP1等位基因变异体与多种人类疾病相关,包括自身免疫性强直性脊柱炎(ankylosing spondylitis,AS)、糖尿病、子宫颈癌以及高血压等.
內質網氨基肽酶1(endoplasmic reticulum aminopeptidase 1,ERAP1)是氨基肽酶 M1傢族中的一箇多功能的酶,在血壓調節、血管髮生、細胞因子受體的胞外區脫落,以及對遞呈至 I 型主要組織相容性抗原複閤物(major histocompatibility complex class I,MHC I)的抗原肽的加工中髮揮作用.ERAP1等位基因變異體與多種人類疾病相關,包括自身免疫性彊直性脊柱炎(ankylosing spondylitis,AS)、糖尿病、子宮頸癌以及高血壓等.
내질망안기태매1(endoplasmic reticulum aminopeptidase 1,ERAP1)시안기태매 M1가족중적일개다공능적매,재혈압조절、혈관발생、세포인자수체적포외구탈락,이급대체정지 I 형주요조직상용성항원복합물(major histocompatibility complex class I,MHC I)적항원태적가공중발휘작용.ERAP1등위기인변이체여다충인류질병상관,포괄자신면역성강직성척주염(ankylosing spondylitis,AS)、당뇨병、자궁경암이급고혈압등.
@@@@ Endoplasmic reticulum aminopeptidase 1 (ERAP1) is a multifunctional enzyme belonging to the M1 family of aminopeptidases with roles in the regulation of blood pressure, angiogenesis, ectodomain shedding of several cytokine receptors, and processing of antigenic peptides presented to MHC class I molecules. Allelic variants of ERAP1 have been linked to a number of human diseases, including the autoimmune disease ankylosing spondylitis (AS), diabetes, some forms of cervical cancer, and hypertension.
