CAJ | 학술논문

姜黄素具有广泛的药理活性,其作为治疗多种疾病的潜力药物的研究正越来越多的引起关注.多个临床Ⅰ期试验已证实,姜黄素口服安全且耐受性好;药动学表明,姜黄素口服不易吸收,生物利用度低.研究显示,姜黄素治疗乳腺癌、结肠癌、肠易激综合征、风湿性关节炎及动脉粥样硬化等有疗效.现总结了姜黄素临床研究的报道,以冀为姜黄素的应用研究提供参考.
강황소구유엄범적약리활성,기작위치료다충질병적잠력약물적연구정월래월다적인기관주.다개림상Ⅰ기시험이증실,강황소구복안전차내수성호;약동학표명,강황소구복불역흡수,생물이용도저.연구현시,강황소치료유선암、결장암、장역격종합정、풍습성관절염급동맥죽양경화등유료효.현총결료강황소림상연구적보도,이기위강황소적응용연구제공삼고.
@@@@Curcumin has been described as a potential agent for many diseases and is attracting much more attention due to its various pharmacological activities. Several phaseⅠtrials have demonstrated curcumin is well tolerated and safe. The pharmacokinetic studies of curcumin indicated in general a low bioavailability of curcumin following oral application. Extensive research has shown that curcumin has pharmacological efficacy in breast cancer, colon cancer, IBS, rheumatoid arthritis, atherosclerosis, and so on. This article summarized the related materials on clinical research of curcumin, and gave a review for application and study in the future.