CAJ | 학술논문

目的:探讨肝硬化患者的凝血功能与血小板参数联合监测的临床意义.方法:对88例肝硬化患者的凝血酶时间(PT)、活化部分凝血酶时间(APTT)、纤维蛋白(FIB)、凝血酶时间(TT)等4项凝血指标和血小板计数(PLT)、平均血小板体积(MPV)、血小板压积(PCT)、血小板分布宽度(PDW)等血小板参数进行测定,并与80例正常人进行对照.结果:与对照组相比,患者组 PT、TT、APTT 显著延长(P<0.01),差别有极显著性意义;FIB、PLT、PCT 明显下降(P<0.01),差别有极显著性意义;MPV、PD 高对照组(P<0.05),差别有显著性意义.随着肝硬化患者 Child-Pugh 评分的升高,PLT、PCT 明显下降,MPV、PDW 明显上升;Child-A、Child-B、Child-C 组间 PLT、PCT、MPV、PDW 相互比较,差异均具有显著意义(P<0.05).结论:凝血4项指标与血小板参数指标的联合监测,对临床判定肝硬化患者的肝功能损害程度和有无出血倾向有重要价值.
목적:탐토간경화환자적응혈공능여혈소판삼수연합감측적림상의의.방법:대88례간경화환자적응혈매시간(PT)、활화부분응혈매시간(APTT)、섬유단백(FIB)、응혈매시간(TT)등4항응혈지표화혈소판계수(PLT)、평균혈소판체적(MPV)、혈소판압적(PCT)、혈소판분포관도(PDW)등혈소판삼수진행측정,병여80례정상인진행대조.결과:여대조조상비,환자조 PT、TT、APTT 현저연장(P<0.01),차별유겁현저성의의;FIB、PLT、PCT 명현하강(P<0.01),차별유겁현저성의의;MPV、PD 고대조조(P<0.05),차별유현저성의의.수착간경화환자 Child-Pugh 평분적승고,PLT、PCT 명현하강,MPV、PDW 명현상승;Child-A、Child-B、Child-C 조간 PLT、PCT、MPV、PDW 상호비교,차이균구유현저의의(P<0.05).결론:응혈4항지표여혈소판삼수지표적연합감측,대림상판정간경화환자적간공능손해정도화유무출혈경향유중요개치.
Objective: To investingate the clinical significance of coagulation index and platelet parameters in pa?tients with liver cirrhosis. Methods: Detecting the factors of PT, APTT, FIB, TT, PLT, MPV, PCT, PDW between 88 hepatocirrhosis patients and 80 normal person. Results: Compared with 80 control group, PT, TT, APTT in he?patocirrhosis patients delayed significantly(P<0.01), and FIB, PLT, PCT decreased obviously(P<0.01), while MPV, PDW were higher(P<0.05). With the Child-Pugh mark increase, PLT, PCT reduced clearly, and MPV, PDW in?creased distinctly. Comparing group Child-A, Child-B, Child-C, this index of PLT, PCT, MPV, PDW, all were have significant differences. Conclusion: It is useful for detecting liver function damage level and weather the bleeding tendency of hepatocirrhosis patients by monitoring the change of coagulation index and platelet parameters in clinical significance.