中国肝脏病杂志(电子版)
中國肝髒病雜誌(電子版)
중국간장병잡지(전자판)
CHINESE JOURNAL OF LIVER DISEASES(ELECTRONIC VERSION)
2013年
1期
37-41
,共5页
吴黎明%陈先祥%程彩涛%王江华%马泽君
吳黎明%陳先祥%程綵濤%王江華%馬澤君
오려명%진선상%정채도%왕강화%마택군
肝肿瘤%CD133%血管内皮生长因子%预后
肝腫瘤%CD133%血管內皮生長因子%預後
간종류%CD133%혈관내피생장인자%예후
Liver neoplasms%CD133%Vascular endothelial growth factors%Prognosis
目的研究肝细胞癌干细胞标记分子CD133与血管内皮生长因子VEGF在肝细胞癌组织中的表达及其预后价值.方法应用免疫组织化学染色方法检测CD133、VEGF在190例肝细胞癌组织中的表达水平,分析其与各项临床病理指标和无瘤生存之间的关系.结果 CD133、VEGF在肝细胞癌组织中的阳性表达率分别为22.1%(42/190)和52.1%(99/190).CD133的表达水平与乙型肝炎病毒感染、肝细胞癌分化程度、镜下血管侵犯比较,差异有显著统计学意义(P<0.05);CD133表达与VEGF表达水平比较,差异有显著统计学意义(P<0.001).生存分析表明,CD133阳性组术后无瘤生存期明显短于CD133阴性组,差异有显著统计学意义(P=0.036).结论肝细胞癌组织中,CD133高表达与VEGF高表达、肝细胞癌低分化以及镜下血管侵犯密切相关;CD133表达水平与肝细胞癌术后无瘤生存呈负相关,CD133可能通过调节VEGF表达水平影响肿瘤局部新生血管形成从而影响肝细胞癌预后.
目的研究肝細胞癌榦細胞標記分子CD133與血管內皮生長因子VEGF在肝細胞癌組織中的錶達及其預後價值.方法應用免疫組織化學染色方法檢測CD133、VEGF在190例肝細胞癌組織中的錶達水平,分析其與各項臨床病理指標和無瘤生存之間的關繫.結果 CD133、VEGF在肝細胞癌組織中的暘性錶達率分彆為22.1%(42/190)和52.1%(99/190).CD133的錶達水平與乙型肝炎病毒感染、肝細胞癌分化程度、鏡下血管侵犯比較,差異有顯著統計學意義(P<0.05);CD133錶達與VEGF錶達水平比較,差異有顯著統計學意義(P<0.001).生存分析錶明,CD133暘性組術後無瘤生存期明顯短于CD133陰性組,差異有顯著統計學意義(P=0.036).結論肝細胞癌組織中,CD133高錶達與VEGF高錶達、肝細胞癌低分化以及鏡下血管侵犯密切相關;CD133錶達水平與肝細胞癌術後無瘤生存呈負相關,CD133可能通過調節VEGF錶達水平影響腫瘤跼部新生血管形成從而影響肝細胞癌預後.
목적연구간세포암간세포표기분자CD133여혈관내피생장인자VEGF재간세포암조직중적표체급기예후개치.방법응용면역조직화학염색방법검측CD133、VEGF재190례간세포암조직중적표체수평,분석기여각항림상병리지표화무류생존지간적관계.결과 CD133、VEGF재간세포암조직중적양성표체솔분별위22.1%(42/190)화52.1%(99/190).CD133적표체수평여을형간염병독감염、간세포암분화정도、경하혈관침범비교,차이유현저통계학의의(P<0.05);CD133표체여VEGF표체수평비교,차이유현저통계학의의(P<0.001).생존분석표명,CD133양성조술후무류생존기명현단우CD133음성조,차이유현저통계학의의(P=0.036).결론간세포암조직중,CD133고표체여VEGF고표체、간세포암저분화이급경하혈관침범밀절상관;CD133표체수평여간세포암술후무류생존정부상관,CD133가능통과조절VEGF표체수평영향종류국부신생혈관형성종이영향간세포암예후.
@@@@Objective To investigate the expression of CD133 and vascular endothelial growth factor (VEGF) in primary lesions of hepatocellular carcinoma (HCC) and its prognostic value. Methods The expression of CD133 and VEGF in 190 patients with HCC were detected by immunohistochemical staining. The correlationship of CD133 expression with the clinicopathologic parameters and features after operation was analyzed. Results The expression of CD133 and VEGF in cancer tissues was 22.1%(42/190) and 52.1%(99/190), respectively. There was significant correlationship between the expression of CD133 and HBV infection, tumor differentiation and microvessel invasion (P<0.05). There was significant correlationship between the expression of CD133 and VEGF (P<0.001). Prognostic analysis demonstrated that the disease-free survival of CD133 positive group was significantly lower than that of CD133 negative group (P = 0.036). Conclusions CD133 expression in HCC correlates significantly with VEGF expression, worse tumor differentiation and microvessel invasion. Patients with CD133 positive expression may suffer from shorter disease-free survival after operation. CD133 may influence the prognosis of HCC by regulating the expression of VEGF.
