CAJ | 학술논문

目的研究人免疫球蛋白联合神经节苷脂对重症手足口病早期干预的效果.方法将符合手足口病重症诊断标准的60例患儿随机分为A组和B组,两组均以小剂量甲强龙、降颅压、清热解毒等对症支持治疗.A组除应用常规方法外,同时静脉滴注人免疫球蛋白治疗.B组除运用常规方法外,静脉滴注人免疫球蛋白联合单唾液酸四己糖神经节苷脂治疗.观察两组患儿神经系统功能评分、主要症状及体征恢复时间、平均住院天数等,评价疗效.结果经过治疗两组患儿神经功能评分都有所改善,B组神经功能评分改善更为明显,两组治疗后比较差异有统计学意义(P<0.05);主要症状、体征恢复时间B组比A组明显缩短,B组与A组相比住院天数明显缩短,差异均有统计学意(P<0.05).结论人免疫球蛋白联合单唾液酸四己糖神经节苷脂治疗HFMD重症在减轻症状,缩短病程,改善神经功能等方面优于单独应用人免疫球蛋白治疗.
목적연구인면역구단백연합신경절감지대중증수족구병조기간예적효과.방법장부합수족구병중증진단표준적60례환인수궤분위A조화B조,량조균이소제량갑강룡、강로압、청열해독등대증지지치료.A조제응용상규방법외,동시정맥적주인면역구단백치료.B조제운용상규방법외,정맥적주인면역구단백연합단타액산사기당신경절감지치료.관찰량조환인신경계통공능평분、주요증상급체정회복시간、평균주원천수등,평개료효.결과경과치료량조환인신경공능평분도유소개선,B조신경공능평분개선경위명현,량조치료후비교차이유통계학의의(P<0.05);주요증상、체정회복시간B조비A조명현축단,B조여A조상비주원천수명현축단,차이균유통계학의(P<0.05).결론인면역구단백연합단타액산사기당신경절감지치료HFMD중증재감경증상,축단병정,개선신경공능등방면우우단독응용인면역구단백치료.
Objective To study the clinical effect of human intravenous immunoglobulin(IVIG) and ganglioside for initial severe hand-foot- mouth disease(HFMD). Methods 60 initial severe HFMD patients were divided into Group A and Group B, the two groups are small doses of methylprednisolone, reducing intracranial pressure. A group in addition to the conventional method, IVIG, Group B, in addition to the use of conventional methods, intravenous IVIG and ganglioside. After treatment, observe the nervous system function scores of the two groups of children, the main symptoms, signs of recovery time, the average days of hospi-talization, to evaluate the efficacy. Results After treatment, two groups of children with neurological score have improved. The nerve function scores of B group improved more significantly than group A(P<0.05); major group B of the symptoms and signs of recovery time is significantly shorter than group A, group B and group A compared length of hospital stay was shortened(P<0.05). Conclusion The drug combination of HFMD severe in relieve symptoms and shorten the course of the disease, and improve neurological function is superior to IVIG treatment.