中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2013年
10期
111-112
,共2页
脑转移瘤%旋转式头部伽玛刀%全脑放疗
腦轉移瘤%鏇轉式頭部伽瑪刀%全腦放療
뇌전이류%선전식두부가마도%전뇌방료
Brain metastases%Rotary cutters head gamma knife%Whole brain radiotherapy
目的:探讨头部伽玛刀联合全脑放疗治疗脑转移瘤的疗效.方法:将120例1~5个脑转移瘤患者随机(根据入院先后顺序,每组一例)分为两组,实验组60例,患者接受全脑放疗30 Gy/15 f/3 w,后加旋转式头部伽玛刀治疗12~16 Gy/1f(WBRT+SRS组);对照组60例,患者接受全脑放疗40 Gy/20 f/4 w(WBRT组).观察两组患者的临床效果和并发症,并进行统计处理,分析两组患者的1年局部控制率和1年生存率.结果:两组患者均取得良好效果,未出现严重毒副作用;实验组和对照组1年局部控制率分别为83.6%、24.3%;1年生存率分别为64.7%、20.1%.实验组1年局部控制率和1年生存率明显高于对照组,差异有统计学意义(P<0.01),且无明显不良反应.结论:头部伽玛刀联合全脑放疗治疗脑转移瘤患者,安全有效,可明显提高脑转移瘤患者的1年局部控制率和1年生存率.
目的:探討頭部伽瑪刀聯閤全腦放療治療腦轉移瘤的療效.方法:將120例1~5箇腦轉移瘤患者隨機(根據入院先後順序,每組一例)分為兩組,實驗組60例,患者接受全腦放療30 Gy/15 f/3 w,後加鏇轉式頭部伽瑪刀治療12~16 Gy/1f(WBRT+SRS組);對照組60例,患者接受全腦放療40 Gy/20 f/4 w(WBRT組).觀察兩組患者的臨床效果和併髮癥,併進行統計處理,分析兩組患者的1年跼部控製率和1年生存率.結果:兩組患者均取得良好效果,未齣現嚴重毒副作用;實驗組和對照組1年跼部控製率分彆為83.6%、24.3%;1年生存率分彆為64.7%、20.1%.實驗組1年跼部控製率和1年生存率明顯高于對照組,差異有統計學意義(P<0.01),且無明顯不良反應.結論:頭部伽瑪刀聯閤全腦放療治療腦轉移瘤患者,安全有效,可明顯提高腦轉移瘤患者的1年跼部控製率和1年生存率.
목적:탐토두부가마도연합전뇌방료치료뇌전이류적료효.방법:장120례1~5개뇌전이류환자수궤(근거입원선후순서,매조일례)분위량조,실험조60례,환자접수전뇌방료30 Gy/15 f/3 w,후가선전식두부가마도치료12~16 Gy/1f(WBRT+SRS조);대조조60례,환자접수전뇌방료40 Gy/20 f/4 w(WBRT조).관찰량조환자적림상효과화병발증,병진행통계처리,분석량조환자적1년국부공제솔화1년생존솔.결과:량조환자균취득량호효과,미출현엄중독부작용;실험조화대조조1년국부공제솔분별위83.6%、24.3%;1년생존솔분별위64.7%、20.1%.실험조1년국부공제솔화1년생존솔명현고우대조조,차이유통계학의의(P<0.01),차무명현불량반응.결론:두부가마도연합전뇌방료치료뇌전이류환자,안전유효,가명현제고뇌전이류환자적1년국부공제솔화1년생존솔.
Objective:To investigate the clinical effect of revolving type head gamma-knife stereotactic radio-surgery(SRS)combined with whole brain radiotherapy(WBRT)in treatment for brain metastases.Method:A total of 120 patients with 1-5 brain metastases were randomly divided into two groups according to admission. Experimental group(60 cases)patients were treated with whole-brain radiotherapy 30 Gy/15 f/3 w.After WBRT,revolving type head gamma-knife treatment was performed 12-16 Gy/1f(WBRT+SRS group). Control group(60 cases)patients were treated with WBRT alone 40 Gy/20 f/4 w(WBRT group). Observed the clinical effect and complications of two groups of patients,analysed the results by statistics to evaluate the 1 year local control rate and the 1 year survival rates.Result:The obtained satisfactory clinical effect in both 2 groups without serious toxity and side effect. 1 year local control rate were 83.6%and 24.3%,1 year survival rate were 64.7%and 20.1%respectively.1 year local control rate and the 1 year survival rate in the experimental group were significantly higher than those in the control group,the difference was statistically significant and there is no obvious adverse reaction(P<0.01).Conclusion:Head gamma knife stereotactic radiotherapy combined with whole brain radiotherapy is a feasible therapeutic option for patients with brain metastases. This therapy is safe and reliable,can significantly improve the 1 year local control rate and the 1 year survival rate of the disease.
