CAJ | 학술논문

目的了解宁波地区已婚妇女宫颈病变及人乳头状瘤病毒感染状况及其分布特点.方法采用多阶段整群随机抽样的方法,在宁波地区抽取城镇与乡村地区>20岁已婚妇女8786例行妇科检查、宫颈液基细胞学检查、HC2 HPV DNA检测及阴道镜下宫颈活检病理检查,进行统计学分析.结果(1)宁波地区宫颈细胞异常率为0.888%,ASC-US 0.546%、LSIL 0.205%、HSIL 0.137%,城乡妇女宫颈细胞异常检出率比较,无统计学差异(P>0.05).(2)阴道镜下宫颈活检病理结果表明ASC-US病例CIN患病率为16.7%,LSIL符合率66.7%,HISL符合率为83.3%,有统计学差异(P<0.01).(3)宁波地区妇女HR-HPV感染率为13.3%,城乡妇女比较,无统计学差异(P>0.05).(4)不同年龄组HR-HPV感染率有统计学差异(P<0.01).35~44岁HR-HPV感染率明显升高,约16.5%.(5)TCT结果ASC-US、LSIL、HSIL,HR HPV感染率为20.8%、66.7%、75.0%,有统计学差异(P<0.01).(6)宫颈上皮内瘤变程度越高,HR-HPV感染率越高(P<0.01).结论宁波地区宫颈细胞异常率为0.888%,HR-HPV感染率为13.3%;HR-HPV感染的高峰年龄为35~44岁;宫颈液基细胞学检查、阴道镜下宫颈活检病理检查结合HC2 HPV DNA检测,对宫颈病变的诊断治疗及随访及宫颈癌的预防有重要意义.
목적료해저파지구이혼부녀궁경병변급인유두상류병독감염상황급기분포특점.방법채용다계단정군수궤추양적방법,재저파지구추취성진여향촌지구>20세이혼부녀8786례행부과검사、궁경액기세포학검사、HC2 HPV DNA검측급음도경하궁경활검병리검사,진행통계학분석.결과(1)저파지구궁경세포이상솔위0.888%,ASC-US 0.546%、LSIL 0.205%、HSIL 0.137%,성향부녀궁경세포이상검출솔비교,무통계학차이(P>0.05).(2)음도경하궁경활검병리결과표명ASC-US병례CIN환병솔위16.7%,LSIL부합솔66.7%,HISL부합솔위83.3%,유통계학차이(P<0.01).(3)저파지구부녀HR-HPV감염솔위13.3%,성향부녀비교,무통계학차이(P>0.05).(4)불동년령조HR-HPV감염솔유통계학차이(P<0.01).35~44세HR-HPV감염솔명현승고,약16.5%.(5)TCT결과ASC-US、LSIL、HSIL,HR HPV감염솔위20.8%、66.7%、75.0%,유통계학차이(P<0.01).(6)궁경상피내류변정도월고,HR-HPV감염솔월고(P<0.01).결론저파지구궁경세포이상솔위0.888%,HR-HPV감염솔위13.3%;HR-HPV감염적고봉년령위35~44세;궁경액기세포학검사、음도경하궁경활검병리검사결합HC2 HPV DNA검측,대궁경병변적진단치료급수방급궁경암적예방유중요의의.
@@@@Objective To investigate the status of cervical lesions and high risk human papil omavirus (HR-HPV) infection among married women in Ningbo city. Methods A total of 8786 married women aged over 20y were selected for gynecological disease screening by cluster sampling method from 6 districts of Ningbo city from April 2010 to May 2011. Liquid-based cervical cytological test, HC2 HPV DNA test as wel as colposcopic examination and cervical biopsy were performed. The data were ana-lyzed with SPSS 17.0 software. Results The rate of abnormal cytology was 0.888%;there was no significant difference between urban and rural women (P>0.05).The detection rates of atypical squamous cel of undetermined significance (ASC-US), low grade squamous intraepithelial lesion (LSIL) and high grade squamous intraepithelial lesion (HSIL) were 0.546%, 0.205% and 0.137%, respectively. The colposcopic examination and cervical biopsy revealed that the morbidity of cervical intraepithelial neo-plasia(CIN) was 16.7%in cytology-diagnosed ASC-US,while the accordant rates for LSIL and HSIL were 66.7%and 83.3%, re-spectively (P<0.01). The HR-HPV infection rate was 13.3%;there was no significant difference between urban and rural (P>0.05). There were significant differences in HR-HPV infection rate among different age groups (P<0.01), the highest rate was in 35~44 age group (16.5%).The HR-HPV infection rates in women with ASC-US, LSIL and HSIL were 20.8%, 66.7%and 75.0%, respectively(P<0.01). The HR-HPV infection rates in patients with CIN 1,2 and 3 were 57.14%,72.72%and 80%(P<0.01). Con-clusion Liquid-based cervical cytological test combined with colposcopic cervical biopsy and HC2 HPV DNA test are of value in screening , diagnosis and treatment of cervical lesions as wel as prevention of cervical cancer.