浙江医学
浙江醫學
절강의학
ZHEJIANG MEDICAL JOURNAL
2013年
6期
453-456
,共4页
减肥%多囊卵巢综合征%瘦素%脂联素%胰岛素抵抗%高雄激素血症
減肥%多囊卵巢綜閤徵%瘦素%脂聯素%胰島素牴抗%高雄激素血癥
감비%다낭란소종합정%수소%지련소%이도소저항%고웅격소혈증
Weight loss%Polycystic ovary syndrome%Leptin%Adiponectin hormone%Insulin resistance%Hyperan-drogenism
目的观察减肥治疗对肥胖型多囊卵巢综合征(PCOS)患者的疗效.方法选取2009年1月至2011年1月肥胖型PCOS患者50例,予减肥治疗3个月,观察体重、血压、BMI、痤疮、多毛等,关注月经变化和排卵情况6个月,检测患者治疗前后血清生殖内分泌激素及糖脂代谢指标.结果减肥3个月后,BMI平均下降2.18±1.99,43例痤疮患者,39例痤疮好转.50例患者均存在月经失调,26例恢复规律的排卵性月经.26例多毛患者,14例减轻(P<0.01).LH、TT、FAI、性激素结合球蛋白(SHBG)、硫酸脱氢表雄酮(DHEAS)、胰岛素样生长因子1(IGF1)、胰岛素样生长因子结合蛋白3(IGFBP3)、FPG、FINS、HOMA-IR、TC、HDL、Apo B、LEP、ADPN等指标减肥后有所改善(均P<0.05).PRL、E2、TG、LDL、ApoA1、脂蛋白a、FSH治疗前后差异均无统计学意义(均P>0.05).结论减肥可以改善PCOS患者的临床症状及血清生殖激素及糖脂代谢指标,是肥胖PCOS患者的有效治疗方法,值得临床应用.
目的觀察減肥治療對肥胖型多囊卵巢綜閤徵(PCOS)患者的療效.方法選取2009年1月至2011年1月肥胖型PCOS患者50例,予減肥治療3箇月,觀察體重、血壓、BMI、痤瘡、多毛等,關註月經變化和排卵情況6箇月,檢測患者治療前後血清生殖內分泌激素及糖脂代謝指標.結果減肥3箇月後,BMI平均下降2.18±1.99,43例痤瘡患者,39例痤瘡好轉.50例患者均存在月經失調,26例恢複規律的排卵性月經.26例多毛患者,14例減輕(P<0.01).LH、TT、FAI、性激素結閤毬蛋白(SHBG)、硫痠脫氫錶雄酮(DHEAS)、胰島素樣生長因子1(IGF1)、胰島素樣生長因子結閤蛋白3(IGFBP3)、FPG、FINS、HOMA-IR、TC、HDL、Apo B、LEP、ADPN等指標減肥後有所改善(均P<0.05).PRL、E2、TG、LDL、ApoA1、脂蛋白a、FSH治療前後差異均無統計學意義(均P>0.05).結論減肥可以改善PCOS患者的臨床癥狀及血清生殖激素及糖脂代謝指標,是肥胖PCOS患者的有效治療方法,值得臨床應用.
목적관찰감비치료대비반형다낭란소종합정(PCOS)환자적료효.방법선취2009년1월지2011년1월비반형PCOS환자50례,여감비치료3개월,관찰체중、혈압、BMI、좌창、다모등,관주월경변화화배란정황6개월,검측환자치료전후혈청생식내분비격소급당지대사지표.결과감비3개월후,BMI평균하강2.18±1.99,43례좌창환자,39례좌창호전.50례환자균존재월경실조,26례회복규률적배란성월경.26례다모환자,14례감경(P<0.01).LH、TT、FAI、성격소결합구단백(SHBG)、류산탈경표웅동(DHEAS)、이도소양생장인자1(IGF1)、이도소양생장인자결합단백3(IGFBP3)、FPG、FINS、HOMA-IR、TC、HDL、Apo B、LEP、ADPN등지표감비후유소개선(균P<0.05).PRL、E2、TG、LDL、ApoA1、지단백a、FSH치료전후차이균무통계학의의(균P>0.05).결론감비가이개선PCOS환자적림상증상급혈청생식격소급당지대사지표,시비반PCOS환자적유효치료방법,치득림상응용.
@@@@Objective To evaluate the effect of weight reduction in obese patients with polycystic ovary syndrome (PCOS). Methods Fifty obese patients with PCOS were recruited in the study from January 2009 to January 2011. The only treatment for patients was weight reduction for three months. The gonadal hormones, blood sugar, blood lipids, body weight, blood pressure, body mass index (BMI) and relevant clinical manifestations were assessed before and after three months of treatment. The men-strual changes and ovulation of patients were followed up for 6 months. Results After three months of weight loss treatment, the BMI was decreased by 2.18±1.99 kg/m2 on average. Among 43 patients who had acne, 39 improved;and of the 28 hairy pa-tients (F-G score 10.88 points), 14 were improved (F-G score 8.65 points). Al 50 patients with menstrual disorder (one had poly-menorrhea, one oligomenorrhea, others had amenorrhea) were fol owed up for 6 months, 26 of them had a restitution of regular cycles. After weight loss, LH, TT, FAI, SHBG, DHEAS, IGF1, IGFBP3, FBG, FINS, HOMA-IR, TC, HDL, APoB, LEP, ADPN im-proved significantly (P<0.05), while PRL, E2, TG, LDL, ApoA1, Lipoprotein A and FSH were not improved (P>0.05). Conclusion Weight loss is an effective treatment for overweight PCOS patients, which can improve the serum level of gonadal hormones, blood sugar, blood lipids and clinical manifestations of PCOS.
