CAJ | 학술논문

目的探讨正清风痛宁治疗膝骨关节炎的临床疗效及对细胞因子白细胞介素1β和肿瘤坏死因子-α的表达的影响.方法将86例膝骨关节炎患者随机分为试验组和对照组,各43例.试验组采用正清风痛宁60 mg/片),60 mg/次,2次/d治疗,对照组采用盐酸氨基葡萄糖(240 mg/片),240 mg/次,2次/d治疗.治疗12周后应用西安大略一麦克马斯特大学骨关节炎调查量表(WOMAC),从关节疼痛、僵硬和活动功能困难程度3个方面进行疗效评价、检测血清白细胞介素1β(IL-1β)和肿瘤坏死因子-α(TNF-α)的表达,同时观察2组不良反应发生率.结果治疗后试验组与对照组WOMAC关节疼痛、僵硬和活动功能困难程度积分均较治疗前下降,差异有统计学意义(P<0.05);试验组上述指标改善情况均优于对照组,差异亦有统计学意义(P<0.05).治疗后两组临床疗效比较差异有统计学意义(P<0.05).两组治疗前后血清IL-1β、TNF-α均下降,试验组较对照组下降明显,差异亦有统计学意义(P<0.05).两组不良反应发生率差异有统计学意义(P<0.05).结论正清风痛宁能够较快有效缓解膝骨关节炎患者症状体征;能抑制血清IL-1β、TNF-α的表达,是治疗膝骨关节炎的有效方法.
목적탐토정청풍통저치료슬골관절염적림상료효급대세포인자백세포개소1β화종류배사인자-α적표체적영향.방법장86례슬골관절염환자수궤분위시험조화대조조,각43례.시험조채용정청풍통저60 mg/편),60 mg/차,2차/d치료,대조조채용염산안기포도당(240 mg/편),240 mg/차,2차/d치료.치료12주후응용서안대략일맥극마사특대학골관절염조사량표(WOMAC),종관절동통、강경화활동공능곤난정도3개방면진행료효평개、검측혈청백세포개소1β(IL-1β)화종류배사인자-α(TNF-α)적표체,동시관찰2조불량반응발생솔.결과치료후시험조여대조조WOMAC관절동통、강경화활동공능곤난정도적분균교치료전하강,차이유통계학의의(P<0.05);시험조상술지표개선정황균우우대조조,차이역유통계학의의(P<0.05).치료후량조림상료효비교차이유통계학의의(P<0.05).량조치료전후혈청IL-1β、TNF-α균하강,시험조교대조조하강명현,차이역유통계학의의(P<0.05).량조불량반응발생솔차이유통계학의의(P<0.05).결론정청풍통저능구교쾌유효완해슬골관절염환자증상체정;능억제혈청IL-1β、TNF-α적표체,시치료슬골관절염적유효방법.
@@@@Objective To observe the effect of zhengqing fengtongning treating knee osteoarthritisand cytokine interleukin-1β, and tumor necrosis factor-αexpression. Methods 86 cases with knee osteoarthritiswere weredivided into two groups.The experimental group was treated with the zhengqing fengtongning(60 mg/tablets,60 mg/times,2 times/d) and the control group were treated using the double finn sodium chloride(240 mg/tablets,240 mg/times,2 times/d).The treatment lasted for 128 weeks. Western Ontario McMaster Universities Osteoarthritis survey scale (WOMAC) were used to evaluate by three aspects of the degree of difficulty from joint pain, stiffness, and activities function, interleukin 1β(IL-1β) and tumor necrosis factor alpha (TNFα) expression of the patient were observed and the untoward effects in the process of treatment were recorded. Results After treatment,the degree of difficulty from joint pain, stiffness, and activities function in experimental group and control group were all improved, the difference was statistically significant (P<0.05);The above indexes were both improved in the experimental group was better than that of control group also have statistically significant difference (P<0.05). After treatment,the clinical curative effect of two sets comparing statistical significance (P<0.05). Serum IL-1βbefore and TNFαdecreased in after treatment, which was more obvious in experimental group than the control group, also hadstatistically significant difference (P<0.05). Adverse reaction rate of two groups of difference was statistically significant (P<0.05). Conclusion The zhengqing fengtongning can effectively relieve knee osteoarthritis symptoms and signs;it can inhibit the serum IL-1β, TNF αexpression, is effective method for the treatment of knee osteoarthritis.