CAJ | 학술논문

目的分析老年轻度认知功能损伤(MCI)的血清唾液酸含量的变化情况,寻找对MCI有价值的神经生物学指标,用以指导临床.方法选取61例健康男性老年人,近期无心脏疾患、肿瘤疾患及感染性疾病,按照MCI诊断标准从61例中选出25例MCI患者作为认知轻度损伤组,其余36例为认知正常组,并分别采集空腹静脉血5 mL,采用荧光-高效液相色谱法对2组的血清进行唾液酸测定.结果认知轻度损伤组的血清唾液酸浓度低于认知正常组的血清唾液酸,差异有显著性(P=0.001).结论健康老年人血清唾液酸水平的降低可能会限制其学习、记忆等认知能力的发展,导致轻度认知功能损伤,提示血清唾液酸是否可以考虑作为MCI的神经生物学指标,用以预测今后的疾病发展.
목적분석노년경도인지공능손상(MCI)적혈청타액산함량적변화정황,심조대MCI유개치적신경생물학지표,용이지도림상.방법선취61례건강남성노년인,근기무심장질환、종류질환급감염성질병,안조MCI진단표준종61례중선출25례MCI환자작위인지경도손상조,기여36례위인지정상조,병분별채집공복정맥혈5 mL,채용형광-고효액상색보법대2조적혈청진행타액산측정.결과인지경도손상조적혈청타액산농도저우인지정상조적혈청타액산,차이유현저성(P=0.001).결론건강노년인혈청타액산수평적강저가능회한제기학습、기억등인지능력적발전,도치경도인지공능손상,제시혈청타액산시부가이고필작위MCI적신경생물학지표,용이예측금후적질병발전.
@@@@Objective To explore the serum sialic acid concentration of old people between the mild cognitive impairment group and the normal cognition group. And try to find the valuable nervous biological indicat-or in MCI. Methods This is a case-control study. We selected 61 cases who were performed a healthy examination from 2009 to 2012. They were all healthy old men and no heart diseases, tumor diseases and infectious diseases recently. According to the criteria of MCI 61 cases were divide into two groups which group was cognitive normal group and the other group was cognitive unnormal group.Then vein blood were extracted from 61 cases. The serum sialic acid concentration were detected with a high performance liquid chromatographic analysis. Results The serum sialic acid of cognitive unnormal group was lower than that of cognitive normal group. There were significant differences between them(P=0.001). Conclusion The lower serum sialic acid content in healthy old peo-ple could limit the development of learning, memory and cognitive ability. Even it could lead to mild cognitive impairment in old people. The result showed that the serum sialic acid content could be as the valuable nervous biological indicator of MCI to predict the outcome of MCI in the future.