CAJ | 학술논문

目的分析末梢血C反应蛋白(CRP)在小儿急性上呼吸道感染诊断及治疗中的应用价值.方法选择急诊首诊为急性上呼吸道感染的患儿494例作为研究对象,对患儿末梢血白细胞(WBC)、中性粒细胞(N)、CRP分布情况进行统计分析,观察CRP正常儿童应用抗菌药物治疗和非抗菌药物治疗的效果.结果494例患儿中,CRP<20 mg/L 390例,CRP>20 mg/L 104例.在CRP升高组中WBC平均值高于CRP正常组,2组间差异有统计学意义(P<0.01);CRP 升高组血清 CRP 与 WBC 和 N 均呈正相关(r 分别为0.439,0.554,P均<0.01).在CRP正常的390例患者中,随机分为非抗生素治疗组和抗生素治疗组,进行5 d内疗效比较,差异无统计学意义(P>0.05).结论末梢血CRP含量的检测有助于临床对小儿上呼吸道是否有细菌感染的早期诊断,对是否应用抗菌药物治疗具有重要的指导作用,可以减少抗菌药物的不合理使用.
목적분석말소혈C반응단백(CRP)재소인급성상호흡도감염진단급치료중적응용개치.방법선택급진수진위급성상호흡도감염적환인494례작위연구대상,대환인말소혈백세포(WBC)、중성립세포(N)、CRP분포정황진행통계분석,관찰CRP정상인동응용항균약물치료화비항균약물치료적효과.결과494례환인중,CRP<20 mg/L 390례,CRP>20 mg/L 104례.재CRP승고조중WBC평균치고우CRP정상조,2조간차이유통계학의의(P<0.01);CRP 승고조혈청 CRP 여 WBC 화 N 균정정상관(r 분별위0.439,0.554,P균<0.01).재CRP정상적390례환자중,수궤분위비항생소치료조화항생소치료조,진행5 d내료효비교,차이무통계학의의(P>0.05).결론말소혈CRP함량적검측유조우림상대소인상호흡도시부유세균감염적조기진단,대시부응용항균약물치료구유중요적지도작용,가이감소항균약물적불합리사용.
Objective research is to study the value of the peripheral blood c-reactive protein (CRP) in diagnosis and treatment of acute upper respiratory tract infection children. Methods A total of 494patients firstly diagnosed as upper respiratory tract from the emergency department were collected. The WBC, N and CRP in peripheral blood were detected. The relationship between antibiotics therapy and out comes was investigated. Results Of 494 cases, CRP level was not more than20mg/L, in 390 cases. And CRP>50 mg/L in104cases. The mean WBC in patients with CRP>50 mg/L was higher than that inpatients withCRP20mg/L (P<0.01). There is a positive correlation among serum CRP, WBC and neutrophils percentage (N) in the 104 unhealthy children, and the statistical index r respectively show as 0.439 and 0.554, and the statistical significance index P is 0.01. he incidence of pyre-tolysis in5d had no difference between antibiotics treated patients and no antibiotics treated patients (P>0.05). Conclusion The peripheral CRP is valuable in the early diagnosis for if patients had already got the acute upper respiratory tract infection caused by bacteria, and it has a important guiding role in the using of antibacterial drug therapy, and it can reduce the unreasonable using of antibacterial drug.