CAJ | 학술논문

黄嘌呤氧化还原酶是一种分布广泛的核酸代谢调控酶类,过渡金属钼和蝶呤等辅因子构成其主要的催化活性位点.本文根据PDB数据库中现存的晶体结构和国内外学者多年来在此酶的催化过程、抑制机制等方面开展的实验和理论研究,对其钼中心与底物和抑制剂之间的相互作用形式进行了综述.
황표령양화환원매시일충분포엄범적핵산대사조공매류,과도금속목화접령등보인자구성기주요적최화활성위점.본문근거PDB수거고중현존적정체결구화국내외학자다년래재차매적최화과정、억제궤제등방면개전적실험화이론연구,대기목중심여저물화억제제지간적상호작용형식진행료종술.
@@@@The xanthine oxidoreductase plays an important role in the metabolism of purines,oxidizing hypoxanthine to xanthine and xanthine to uric acid.The enzyme features active sites composed of a single Mo atome coordinated by one molybdopterin-based ligand.In this paper the interaction models of the molybdopterin and ligands are reviewed according to the experimental and theoretical studies of the reactivity and structures of the xanthine oxidoreductase.