CAJ | 학술논문

目的探讨缺氧诱导因子-1α(hypoxia inducible factor-1α,HIF-1α)、血管内皮细胞生长因子(vascular endothelial growth factor,VEGF)和转化生长因子β1(transforming growth factor β1,TGF-β1)在非小细胞肺癌(non-small cell lung cancer,NSCLC)中的表达及其临床意义.方法采用免疫组织化学 SP 法检测58例 NSCLC 患者术后癌组织和13例正常肺组织中 HIF-1α、VEGF 和 TGF-β1的表达水平.结果 NSCLC 组织中 HIF-1α、VEGF 和 TGF-β1的阳性表达率均明显高于正常肺组织,其表达与临床分期和有无淋巴结转移有关(P<0.01),与性别、年龄、病理类型和分化程度无关(P>0.05),三项指标在 NSCLC 组织中的表达呈正相关(P<0.05).结论 HIF-1α、VEGF 和 TGF-β1在 NSCLC 中的高表达可能与 NSCLC的侵袭和转移密切相关.
목적탐토결양유도인자-1α(hypoxia inducible factor-1α,HIF-1α)、혈관내피세포생장인자(vascular endothelial growth factor,VEGF)화전화생장인자β1(transforming growth factor β1,TGF-β1)재비소세포폐암(non-small cell lung cancer,NSCLC)중적표체급기림상의의.방법채용면역조직화학 SP 법검측58례 NSCLC 환자술후암조직화13례정상폐조직중 HIF-1α、VEGF 화 TGF-β1적표체수평.결과 NSCLC 조직중 HIF-1α、VEGF 화 TGF-β1적양성표체솔균명현고우정상폐조직,기표체여림상분기화유무림파결전이유관(P<0.01),여성별、년령、병리류형화분화정도무관(P>0.05),삼항지표재 NSCLC 조직중적표체정정상관(P<0.05).결론 HIF-1α、VEGF 화 TGF-β1재 NSCLC 중적고표체가능여 NSCLC적침습화전이밀절상관.
@@@@Objective To determine the expression and clinical significance of HIF-1α,VEGF and TGF-β1 in non-small cell lung cancer(NSCLC). Method The immunohistochemical SP method was used to analyze expression of HIF-1α,VEGF and TGF-β1 in 85 samples of NSCLC tissue and 13 samples of normal lung tissue. Results A greater proportion of NSCLC tissue than normal lung tissue was positive for HIF-1α,VEGF and TGF-β1.Expression of these proteins positively correlated with NSCLC clinical stage and lymph node metastasis (P<0.01).However,no correlation was observed between expression of HIF-1α,VEGF and TGF-β1 and other clinico-pathological features such as age,sex,pathology type or degree of differentiation(P>0.05).Levels of HIF-1α,VEGF and TGF-β1 corre-lated positively with one another in NSCLC tissue(P<0.05). Conclusion Elevated expression of HIF-1α,VEGF and TGF-β1 may be associated with tumor invasion and metastasis in NSCLC.