CAJ | 학술논문

目的通过对肝细胞性肝癌(hepatocellular carcinoma,HCC)住院病例的调查,探讨广西贵港地区乙型肝炎病毒(简称乙肝)感染及 HCC 家族史与 HCC 患者住院年龄的关系.方法应用临床流行病学横断面的研究方法,以2004~2008年贵港市人民医院首次住院的 HCC 患者1365例为研究对象.回顾性构建调查表的数据库,对贵港地区乙肝感染及HCC 家族史与 HCC 患者住院年龄进行相关性分析.结果 HCC 家族史(+)者住院年龄较 HCC 家族史(-)者小(P约0.05);HCC 病例中乙肝(-)者住院年龄与乙肝(+)者的差异无统计学意义(P=0.738);以乙肝(-)且 HCC 家族史(-)者作为参照组,乙肝(+)且 HCC 家族史(-)组与之比较,患者住院年龄的差异无统计学意义(P=0.443),乙肝(-)且 HCC 家族史(+)者及乙肝(+)且 HCC 家族史(+)者的住院年龄均偏小(P 均约0.05).结论①无论是否有乙肝感染,HCC 家族史(+)的肝癌患者住院年龄均较 HCC 家族史(-)者小;②HCC 家族史及乙肝感染史与贵港地区 HCC 患者的住院年龄有关系.
목적통과대간세포성간암(hepatocellular carcinoma,HCC)주원병례적조사,탐토엄서귀항지구을형간염병독(간칭을간)감염급 HCC 가족사여 HCC 환자주원년령적관계.방법응용림상류행병학횡단면적연구방법,이2004~2008년귀항시인민의원수차주원적 HCC 환자1365례위연구대상.회고성구건조사표적수거고,대귀항지구을간감염급HCC 가족사여 HCC 환자주원년령진행상관성분석.결과 HCC 가족사(+)자주원년령교 HCC 가족사(-)자소(P약0.05);HCC 병례중을간(-)자주원년령여을간(+)자적차이무통계학의의(P=0.738);이을간(-)차 HCC 가족사(-)자작위삼조조,을간(+)차 HCC 가족사(-)조여지비교,환자주원년령적차이무통계학의의(P=0.443),을간(-)차 HCC 가족사(+)자급을간(+)차 HCC 가족사(+)자적주원년령균편소(P 균약0.05).결론①무론시부유을간감염,HCC 가족사(+)적간암환자주원년령균교 HCC 가족사(-)자소;②HCC 가족사급을간감염사여귀항지구 HCC 환자적주원년령유관계.
@@@@Objective To explore potential associations of HBV infection and family history of hepatocellular carcinoma(HCC)with age at HCC diagnosis. Methods A total of 1 365 new patients with HCC treated between 2004 and 2008 at the People's Hospital of Guigang were included in a cross-sectional study,and data were analyzed retrospectively using Excel. Results Patients with a family history of HCC presented the disease at a signif-icantly earlier age than did those with no family history(P<0.05).Age at diagnosis did not differ significantly between patients who were HBsAg-negative and patients who were HBsAg-positive (P=0.738).Among patients with no family history of HCC,age at HCC diagnosis did not differ significantly between those who were HBsAg-positive and those who were HBsAg-negative(P=0.443). However,age at HCC diagnosis of patients with a family history of the disease, regardless of their HBsAg status,was significantly lower than that of HBsAg-negative patients with no family history(P<0.05). Conclusion Among patients with HCC in Guigang City,those with a family history of the disease are diagnosed at an earlier age than are those with no family history,regardless of their HBsAg status.