CAJ | 학술논문

背景:近来研究发现高迁移率族蛋白 B1在各种炎症中作为一种重要的炎症因子发挥了明显作用.目的:测定种植体周围黏膜炎患者龈沟液中高迁移率族蛋白 B1的水平,探讨高速泳动族蛋白 B1与种植体周围黏膜炎的关系.方法:选择健康种植体(n=39)、轻度种植体周围黏膜炎(n=24)和中度种植体周围黏膜炎(n=16)患者,测定种植体周围龈沟液量、龈沟液中高速泳动族蛋白 B1总量及浓度;同时检测种植体周围黏膜炎的牙龈指数、菌斑指数、探诊深度和松动度.结果与结论:轻度种植体周围黏膜炎组龈沟液量、高迁移率族蛋白 B1总量和浓度高于健康种植体组(P <0.01),但低于中度种植体周围黏膜炎组(P <0.01).牙龈指数与龈沟液量之间存在正相关关系(P <0.01),牙龈指数、菌斑指数与高迁移率族蛋白 B1总量及浓度存在正相关关系(P <0.01),探诊深度、松动度与高迁移率族蛋白 B1浓度及总量间无明显相关性(P >0.05).表明种植体周围龈沟液量及龈沟液中高迁移率族蛋白 B1水平与种植体周围黏膜炎的病变程度有关,检测龈沟液中高速泳动族蛋白 B1水平可作为临床诊断种植体周围黏膜炎的客观指标.
배경:근래연구발현고천이솔족단백 B1재각충염증중작위일충중요적염증인자발휘료명현작용.목적:측정충식체주위점막염환자간구액중고천이솔족단백 B1적수평,탐토고속영동족단백 B1여충식체주위점막염적관계.방법:선택건강충식체(n=39)、경도충식체주위점막염(n=24)화중도충식체주위점막염(n=16)환자,측정충식체주위간구액량、간구액중고속영동족단백 B1총량급농도;동시검측충식체주위점막염적아간지수、균반지수、탐진심도화송동도.결과여결론:경도충식체주위점막염조간구액량、고천이솔족단백 B1총량화농도고우건강충식체조(P <0.01),단저우중도충식체주위점막염조(P <0.01).아간지수여간구액량지간존재정상관관계(P <0.01),아간지수、균반지수여고천이솔족단백 B1총량급농도존재정상관관계(P <0.01),탐진심도、송동도여고천이솔족단백 B1농도급총량간무명현상관성(P >0.05).표명충식체주위간구액량급간구액중고천이솔족단백 B1수평여충식체주위점막염적병변정도유관,검측간구액중고속영동족단백 B1수평가작위림상진단충식체주위점막염적객관지표.
BACKGROUND: Recent studies have found that high mobility group box 1 protein (HMGB-1) as an important inflammatory factor plays a significant role in various inflammations. OBJECTIVE: To determine the HMGB-1 level in the peri-implant gingival crevicular fluid and to investiage the correlation of HMGB-1 and peri-implant mucositis. METHODS: Patients with healthy implant (n=39), with mild peri-implant mucositis (n=24) and moderate peri-implant mucositis (n=16) were enrol ed. The amount of peri-implant gingival crevicular fluid, total amount of HMGB-1 and levels of HMGB-1 were detected. Clinical parameters were measured to investigate their relationships, including gingival index, mobility, plaque index, probing depth. RESULTS AND CONCLUSION: The amount of peri-implant gingival crevicular fluid, total amount of HMGB-1 and levels of HMGB-1 were significantly higher in the patients with mild peri-implant mucositis than in the healthy implant patients (P < 0.01), but lower than the moderate peri-implant mucositis patients (P < 0.01). Gingival crevicular fluid volume was positively correlated with gingival index and plaque index (P < 0.01). The total amount of HMGB-1 was positively correlated with gingival index and probing depth (P < 0.01). No significant difference was found between probing depth and mobility and the level and total amount of HMGB-1. This investigation show that HMGB-1 level in the gingival crevicular fluid may be as a diagnostic marker for peri-implant mucositis.