中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2013年
3期
440-444
,共5页
刘金盼%王明国%李静%杨世茂
劉金盼%王明國%李靜%楊世茂
류금반%왕명국%리정%양세무
生物材料%组织工程口腔材料%高迁移率族蛋白 B1%种植体周围黏膜炎%临床指标%相关性
生物材料%組織工程口腔材料%高遷移率族蛋白 B1%種植體週圍黏膜炎%臨床指標%相關性
생물재료%조직공정구강재료%고천이솔족단백 B1%충식체주위점막염%림상지표%상관성
biomaterials%tissue-engineered oral materials%high mobility group box 1 protein%peri-implant mucositis%clinical parameters%correlativity
背景:近来研究发现高迁移率族蛋白 B1在各种炎症中作为一种重要的炎症因子发挥了明显作用.目的:测定种植体周围黏膜炎患者龈沟液中高迁移率族蛋白 B1的水平,探讨高速泳动族蛋白 B1与种植体周围黏膜炎的关系.方法:选择健康种植体(n=39)、轻度种植体周围黏膜炎(n=24)和中度种植体周围黏膜炎(n=16)患者,测定种植体周围龈沟液量、龈沟液中高速泳动族蛋白 B1总量及浓度;同时检测种植体周围黏膜炎的牙龈指数、菌斑指数、探诊深度和松动度.结果与结论:轻度种植体周围黏膜炎组龈沟液量、高迁移率族蛋白 B1总量和浓度高于健康种植体组(P <0.01),但低于中度种植体周围黏膜炎组(P <0.01).牙龈指数与龈沟液量之间存在正相关关系(P <0.01),牙龈指数、菌斑指数与高迁移率族蛋白 B1总量及浓度存在正相关关系(P <0.01),探诊深度、松动度与高迁移率族蛋白 B1浓度及总量间无明显相关性(P >0.05).表明种植体周围龈沟液量及龈沟液中高迁移率族蛋白 B1水平与种植体周围黏膜炎的病变程度有关,检测龈沟液中高速泳动族蛋白 B1水平可作为临床诊断种植体周围黏膜炎的客观指标.
揹景:近來研究髮現高遷移率族蛋白 B1在各種炎癥中作為一種重要的炎癥因子髮揮瞭明顯作用.目的:測定種植體週圍黏膜炎患者齦溝液中高遷移率族蛋白 B1的水平,探討高速泳動族蛋白 B1與種植體週圍黏膜炎的關繫.方法:選擇健康種植體(n=39)、輕度種植體週圍黏膜炎(n=24)和中度種植體週圍黏膜炎(n=16)患者,測定種植體週圍齦溝液量、齦溝液中高速泳動族蛋白 B1總量及濃度;同時檢測種植體週圍黏膜炎的牙齦指數、菌斑指數、探診深度和鬆動度.結果與結論:輕度種植體週圍黏膜炎組齦溝液量、高遷移率族蛋白 B1總量和濃度高于健康種植體組(P <0.01),但低于中度種植體週圍黏膜炎組(P <0.01).牙齦指數與齦溝液量之間存在正相關關繫(P <0.01),牙齦指數、菌斑指數與高遷移率族蛋白 B1總量及濃度存在正相關關繫(P <0.01),探診深度、鬆動度與高遷移率族蛋白 B1濃度及總量間無明顯相關性(P >0.05).錶明種植體週圍齦溝液量及齦溝液中高遷移率族蛋白 B1水平與種植體週圍黏膜炎的病變程度有關,檢測齦溝液中高速泳動族蛋白 B1水平可作為臨床診斷種植體週圍黏膜炎的客觀指標.
배경:근래연구발현고천이솔족단백 B1재각충염증중작위일충중요적염증인자발휘료명현작용.목적:측정충식체주위점막염환자간구액중고천이솔족단백 B1적수평,탐토고속영동족단백 B1여충식체주위점막염적관계.방법:선택건강충식체(n=39)、경도충식체주위점막염(n=24)화중도충식체주위점막염(n=16)환자,측정충식체주위간구액량、간구액중고속영동족단백 B1총량급농도;동시검측충식체주위점막염적아간지수、균반지수、탐진심도화송동도.결과여결론:경도충식체주위점막염조간구액량、고천이솔족단백 B1총량화농도고우건강충식체조(P <0.01),단저우중도충식체주위점막염조(P <0.01).아간지수여간구액량지간존재정상관관계(P <0.01),아간지수、균반지수여고천이솔족단백 B1총량급농도존재정상관관계(P <0.01),탐진심도、송동도여고천이솔족단백 B1농도급총량간무명현상관성(P >0.05).표명충식체주위간구액량급간구액중고천이솔족단백 B1수평여충식체주위점막염적병변정도유관,검측간구액중고속영동족단백 B1수평가작위림상진단충식체주위점막염적객관지표.
BACKGROUND: Recent studies have found that high mobility group box 1 protein (HMGB-1) as an important inflammatory factor plays a significant role in various inflammations. OBJECTIVE: To determine the HMGB-1 level in the peri-implant gingival crevicular fluid and to investiage the correlation of HMGB-1 and peri-implant mucositis. METHODS: Patients with healthy implant (n=39), with mild peri-implant mucositis (n=24) and moderate peri-implant mucositis (n=16) were enrol ed. The amount of peri-implant gingival crevicular fluid, total amount of HMGB-1 and levels of HMGB-1 were detected. Clinical parameters were measured to investigate their relationships, including gingival index, mobility, plaque index, probing depth. RESULTS AND CONCLUSION: The amount of peri-implant gingival crevicular fluid, total amount of HMGB-1 and levels of HMGB-1 were significantly higher in the patients with mild peri-implant mucositis than in the healthy implant patients (P < 0.01), but lower than the moderate peri-implant mucositis patients (P < 0.01). Gingival crevicular fluid volume was positively correlated with gingival index and plaque index (P < 0.01). The total amount of HMGB-1 was positively correlated with gingival index and probing depth (P < 0.01). No significant difference was found between probing depth and mobility and the level and total amount of HMGB-1. This investigation show that HMGB-1 level in the gingival crevicular fluid may be as a diagnostic marker for peri-implant mucositis.