CAJ | 학술논문

生物材料%生物材料综述%自膨胀式支架%支架置入%脑血管%颅内动脉疾病%颅内动脉瘤%颈动脉狭窄%镍钛合金%形状记忆效应%并发症%再狭窄生物材料%生物材料綜述%自膨脹式支架%支架置入%腦血管%顱內動脈疾病%顱內動脈瘤%頸動脈狹窄%鎳鈦閤金%形狀記憶效應%併髮癥%再狹窄
생물재료%생물재료종술%자팽창식지가%지가치입%뇌혈관%로내동맥질병%로내동맥류%경동맥협착%얼태합금%형상기억효응%병발증%재협착
biomaterials%biomaterial review%self-expanding stents%stent implantation%intracranial arterial diseases%intracranial aneurysms%carotid stenosis%nickel-titanium alloy%shape memory effect%complications%restenosis

背景:随着冠脉血管支架和外周血管支架置入技术的成熟,如今自膨胀式支架正成为国内外医疗器械厂商致力于开发的重点和热点产品,由于脑血管相当迂曲和细小,以及置入风险比其他部位血管高很多,因此自膨胀式支架的开发要难度很大.首要任务就是选用合适的生物医用材料,如何提高脑血管病支架材料的安全性、减少并发症是该项技术的要点和难点.目的:分析不同自膨胀式支架材料在脑血管介入中的应用的相关文献,比较自膨胀式支架置入与传统的脑血管病治疗方法的优势,以及安全性和相关并发症等问题.方法:收集不同自膨胀式支架治疗不同脑血管病的相关文献,就临床开始使用以及正在研究开发的各类自膨胀式支架材料的物理性能、化学性能和生物相容性进行对比分析,比较不同治疗方法的优缺点.结果与结论:关于血管内治疗的方案,仍然缺乏统一的标准.不同治疗方法都存在一定的弊端,各种治疗方案的安全性及有效性尚需要大规模、前瞻性、随即对照试验予以证实.随着自膨胀式支架材料的更新与发展,自膨胀式支架的应用可成为脑血管病的重要治疗方法.
배경:수착관맥혈관지가화외주혈관지가치입기술적성숙,여금자팽창식지가정성위국내외의료기계엄상치력우개발적중점화열점산품,유우뇌혈관상당우곡화세소,이급치입풍험비기타부위혈관고흔다,인차자팽창식지가적개발요난도흔대.수요임무취시선용합괄적생물의용재료,여하제고뇌혈관병지가재료적안전성、감소병발증시해항기술적요점화난점.목적:분석불동자팽창식지가재료재뇌혈관개입중적응용적상관문헌,비교자팽창식지가치입여전통적뇌혈관병치료방법적우세,이급안전성화상관병발증등문제.방법:수집불동자팽창식지가치료불동뇌혈관병적상관문헌,취림상개시사용이급정재연구개발적각류자팽창식지가재료적물이성능、화학성능화생물상용성진행대비분석,비교불동치료방법적우결점.결과여결론:관우혈관내치료적방안,잉연결핍통일적표준.불동치료방법도존재일정적폐단,각충치료방안적안전성급유효성상수요대규모、전첨성、수즉대조시험여이증실.수착자팽창식지가재료적경신여발전,자팽창식지가적응용가성위뇌혈관병적중요치료방법.
@@@@BACKGROUND: With the development of coronary vascular stents and peripheral vascular stent implantation technology, the coronary vascular stents and peripheral vascular stent technology, the self-expanding stent is becoming the key and hot product dedicated to the development by the domestic and international medical equipment manufacturers. As the brain vessel is quite tortuous and smal , and the risk of placement is much higher than other parts, the development of self-expanding stent is very difficult.The primary task is the appropriate choice of biomedical materials, while, how to improve the security of cerebrovascular disease scaffold materials and reduce the complications is the main point and difficulty. OBJECTIVE: To analyze the literatures on the application of different self-expanding stents in cerebrovascular intervention, and to compare the advantages of self-expanding stent implantation and traditional treatment methods of cerebrovascular diseases, as wel as to analyze the security and complications. METHODS: The literatures on the treatment of different cerebrovascular diseases with different self-expanding stents were col ected. The physical properties, chemical properties and biocompatibility of various types of self-expanding stents were comparatively analyzed which were clinical y used and in development. The disadvantages and advantages of different treatment methods were compared. RESULTS AND CONCLUSION: There stil lacks of a unified standard of endovascular treatment program. Each treatment method has their own advantages and disadvantages, the safety and efficacy of various treatment programs stil require large-scale, prospective, randomized control ed trials to be confirmed. With the update and development of self-expanding stent materials, the application of self-expanding stent has become the important treatment method for cerebrovascular diseases.