CAJ | 학술논문

背景:口腔溃疡是由多种原因引起的口腔黏膜常见病,常以局部用药的治疗为主,口腔溃疡膜的应用可以将药物直接作用于溃疡创面,溃疡膜的缓释设计延长了药物的作用时间,使局部的药物浓度明显增高,有利于药效的发挥.目的:探讨口腔溃疡膜材料及口腔溃疡载药膜材料的制备方法以及检测指标.方法:口腔溃疡膜可以通过持续的黏附于溃疡创面,阻隔口腔唾液及口腔菌群对溃疡创面的侵蚀,起到阻碍细菌及保护创面的作用.口腔溃疡载药膜材料可分为合成高分子成膜材料和天然高分子聚合物成膜材料.常用于制备口腔溃疡膜的材料有聚乙烯醇、羟丙基甲基纤维素、羧甲基纤维素等.结果与结论:壳聚糖口腔溃疡膜具有抗菌、抗氧化的作用,同时可以止血、消炎,促进溃疡组织愈合的作用.壳聚糖和中药载药膜材料可以使溃疡面积明显缩小,壳聚糖膜在治疗有效率方面明显高于抗生素膜.口腔溃疡载药膜制备的过程中,常用高效液相色谱法测定药物浓度,通过线性关系、回收率试验、黏附力和黏附时间的测量,分析溃疡载药膜材料作用后局部的药物浓度、作用时间以及黏附情况.
배경:구강궤양시유다충원인인기적구강점막상견병,상이국부용약적치료위주,구강궤양막적응용가이장약물직접작용우궤양창면,궤양막적완석설계연장료약물적작용시간,사국부적약물농도명현증고,유리우약효적발휘.목적:탐토구강궤양막재료급구강궤양재약막재료적제비방법이급검측지표.방법:구강궤양막가이통과지속적점부우궤양창면,조격구강타액급구강균군대궤양창면적침식,기도조애세균급보호창면적작용.구강궤양재약막재료가분위합성고분자성막재료화천연고분자취합물성막재료.상용우제비구강궤양막적재료유취을희순、간병기갑기섬유소、최갑기섬유소등.결과여결론:각취당구강궤양막구유항균、항양화적작용,동시가이지혈、소염,촉진궤양조직유합적작용.각취당화중약재약막재료가이사궤양면적명현축소,각취당막재치료유효솔방면명현고우항생소막.구강궤양재약막제비적과정중,상용고효액상색보법측정약물농도,통과선성관계、회수솔시험、점부력화점부시간적측량,분석궤양재약막재료작용후국부적약물농도、작용시간이급점부정황.
@@@@BACKGROUND: Oral ulcer is a common disease in the oral mucosa caused by a variety of reasons, which is often treated with local administration. The application of oral ulcer film can apply the drugs directly on the ulcer wounds, and the sustained-release design of the ulcer films can prolong the action duration of the drugs and significantly increase the local drug concentration, which is conducive to playing the drug’s efficacy. OBJECTIVE: To explore the preparation method and detection index of membrane materials and drug loading membrane materials used for the treatment of oral ulcers. METHODS: Membranes for mouth ulcers can be continuously adhered onto the ulcer wounds and then block the erosion of saliva and oral flora to ulcer wounds, which play a role in preventing the bacteria against the wound. The drug loading membrane materials can be divided into synthetic polymer materials and natural polymer materials. Materials commonly used in the preparation of mouth ulcer membranes include polyvinyl alcohol, hydroxypropyl methyl cel ulose, carboxymethyl cel ulose. RESULTS AND CONCLUSION: Chitosan membranes for mouth ulcers have the advantages of anti-bacteria, anti-oxidation, bleeding, and anti-inflammation, thereby promoting healing of ulcer tissue. The chitosan and Chinese herb loading membrane materials can significantly reduce the ulcer area, and the effect of chitosan membrane is better than that of antibiotics membrane. During the preparation of drug loading membranes for mouth ulcers, high-performance liquid chromatographic method is the commonly used method to detect the drug concentration. The local drug concentration, action time and adhesion are analyzed through the detection of linear relationship, recovery test, adhesion and adhesion time.