CAJ | 학술논문

骨关节植入物%骨关节植入物学术探讨%髋关节置换%深静脉血栓%体质量指数%假体类型%高血压%糖尿病%血小板%炎性细胞因子%细胞黏附分子%白细胞介素 1%白细胞介素 6%白细胞介素 10%肿瘤坏死因子%低分子肝素骨關節植入物%骨關節植入物學術探討%髖關節置換%深靜脈血栓%體質量指數%假體類型%高血壓%糖尿病%血小闆%炎性細胞因子%細胞黏附分子%白細胞介素 1%白細胞介素 6%白細胞介素 10%腫瘤壞死因子%低分子肝素
골관절식입물%골관절식입물학술탐토%관관절치환%심정맥혈전%체질량지수%가체류형%고혈압%당뇨병%혈소판%염성세포인자%세포점부분자%백세포개소 1%백세포개소 6%백세포개소 10%종류배사인자%저분자간소

背景:深静脉血栓是髋关节置换后常见的并发症,随着髋关节置换的广泛应用,深静脉血栓的发生率在逐渐升高.目的:研究髋关节置换后深静脉血栓形成的风险因素和发生机制以及药物治疗效果,为临床患者提供更好的防治选择.方法:对髋关节置换后的患者进行随访,统计深静脉血栓形成的发生率以及相关危险因素,用免疫生化检测的方法检测髋关节治疗前后炎性细胞因子和细胞粘附分子的表达水平,明确深静脉血栓的发生机制,并给予低分子肝素进行预防治疗,明确防治应用效果.结果与结论:高龄、女性、肥胖、双侧髋关节同时置换、治疗时采用全身麻醉、应用骨水泥型假体、长期卧床、合并各种代谢性疾病均是髋关节置换后深静脉血栓发生的危险因素,大多数文献研究显示 O 型血型属于保护因素.在髋关节置换后深静脉血栓形成的过程中炎性细胞因子和细胞黏附分子的表达水平提示血栓发生的风险.应用低分子肝素可以降低髋关节置换后深静脉血栓的发生率,具有良好的防治作用.
배경:심정맥혈전시관관절치환후상견적병발증,수착관관절치환적엄범응용,심정맥혈전적발생솔재축점승고.목적:연구관관절치환후심정맥혈전형성적풍험인소화발생궤제이급약물치료효과,위림상환자제공경호적방치선택.방법:대관관절치환후적환자진행수방,통계심정맥혈전형성적발생솔이급상관위험인소,용면역생화검측적방법검측관관절치료전후염성세포인자화세포점부분자적표체수평,명학심정맥혈전적발생궤제,병급여저분자간소진행예방치료,명학방치응용효과.결과여결론:고령、녀성、비반、쌍측관관절동시치환、치료시채용전신마취、응용골수니형가체、장기와상、합병각충대사성질병균시관관절치환후심정맥혈전발생적위험인소,대다수문헌연구현시 O 형혈형속우보호인소.재관관절치환후심정맥혈전형성적과정중염성세포인자화세포점부분자적표체수평제시혈전발생적풍험.응용저분자간소가이강저관관절치환후심정맥혈전적발생솔,구유량호적방치작용.
@@@@BACKGROUND: Deep vein thrombosis is a common complication after hip replacement. With the extensive application of the hip replacement, the incidence of deep vein thrombosis is gradual y increased. OBJECTIVE: To study the risk factors and mechanism of deep vein thrombosis after hip replacement as wel as the effect of drug treatment, in order to provide better prevention and treatment options for clinical patients.METHODS: The patients with hip replacement were fol owed-up to analyze the incidence rate and related risk factors of deep vein thrombosis. The expressions of inflammatory cytokines and cel adhesion molecules before and after hip replacement were detected with immunohistochemical detection method to identify the mechanism of deep vein thrombosis, and give the low molecular weight heparin for prevention and treatment as wel as to indentify the application effect of prevention and treatment. RESULTS AND CONSLUSION: Elderly, females, obesity, bilateral hip replacement, general anesthesia in the treatment, application of bone cement prosthesis, long-time bed rest, merged with various metabolic diseases are the risk factors of deep vein thrombosis after hip replacement. Most studies have shown that O-blood type is the protective factor. The expression levels of inflammatory cytokines and cel adhesion molecules can indicate the incidence of deep vein thrombosis after hip replacement. Low molecular weight heparin can reduce the incidence of deep vein thrombosis after hip replacement, which has a good effect in the prevention and treatment of deep vein thrombosis.