中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2013年
6期
1107-1110
,共4页
干细胞%干细胞综述%骨髓%间充质干细胞%软骨%基因治疗%基因修饰%组织工程%生物活性因子%载体
榦細胞%榦細胞綜述%骨髓%間充質榦細胞%軟骨%基因治療%基因脩飾%組織工程%生物活性因子%載體
간세포%간세포종술%골수%간충질간세포%연골%기인치료%기인수식%조직공정%생물활성인자%재체
stem cells%stem cel review%bone marrow%mesenchymal stem cells%cartilage%gene therapy%gene modification%tissue engineering%biological active factors%vector
背景:随着生物技术的发展,通过转基因技术修饰细胞,从而获得长期稳定表达的生物活性因子以治疗关节软骨损伤逐渐引起重视.目的:就基因修饰的骨髓间充质干细胞在修复关节软骨损伤中的应用作一综述.方法:由第一作者检索1990至2011年 PubMed 数据库(http://www.ncbi.nlm.nih.gov/PubMed)有关基因修饰骨髓间充质干细胞修复关节软骨损伤的文献,英文检索词为“cartilage,gene therapy, mesenchymal stem cel s,tissue engineering,bioactive factor,vector”.共纳入15篇文献归纳总结.结果与结论:骨髓间充质干细胞已被广泛应用于修复关节软骨损伤.通过转基因技术将特定外源基因导入骨髓间充质干细胞,联合细胞治疗和基因治疗可达到更好的治疗效果,在关节软骨损伤的治疗中有广阔的应用前景.
揹景:隨著生物技術的髮展,通過轉基因技術脩飾細胞,從而穫得長期穩定錶達的生物活性因子以治療關節軟骨損傷逐漸引起重視.目的:就基因脩飾的骨髓間充質榦細胞在脩複關節軟骨損傷中的應用作一綜述.方法:由第一作者檢索1990至2011年 PubMed 數據庫(http://www.ncbi.nlm.nih.gov/PubMed)有關基因脩飾骨髓間充質榦細胞脩複關節軟骨損傷的文獻,英文檢索詞為“cartilage,gene therapy, mesenchymal stem cel s,tissue engineering,bioactive factor,vector”.共納入15篇文獻歸納總結.結果與結論:骨髓間充質榦細胞已被廣汎應用于脩複關節軟骨損傷.通過轉基因技術將特定外源基因導入骨髓間充質榦細胞,聯閤細胞治療和基因治療可達到更好的治療效果,在關節軟骨損傷的治療中有廣闊的應用前景.
배경:수착생물기술적발전,통과전기인기술수식세포,종이획득장기은정표체적생물활성인자이치료관절연골손상축점인기중시.목적:취기인수식적골수간충질간세포재수복관절연골손상중적응용작일종술.방법:유제일작자검색1990지2011년 PubMed 수거고(http://www.ncbi.nlm.nih.gov/PubMed)유관기인수식골수간충질간세포수복관절연골손상적문헌,영문검색사위“cartilage,gene therapy, mesenchymal stem cel s,tissue engineering,bioactive factor,vector”.공납입15편문헌귀납총결.결과여결론:골수간충질간세포이피엄범응용우수복관절연골손상.통과전기인기술장특정외원기인도입골수간충질간세포,연합세포치료화기인치료가체도경호적치료효과,재관절연골손상적치료중유엄활적응용전경.
@@@@BACKGROUND: Bone marrow mesenchymal stem cells have the potential of self-renewal and multiple differentiations, and can be induced into osteoblasts and chondrocytes under certain conditions, so they have been widely used for articular cartilage repair in recent studies. OBJECTIVE: To review application of gene-modified bone marrow mesenchymal stem cells in repair of articular cartilage injury. METHODS: A computer-based online retrieval of PubMed database (http://www.ncbi.nlm.nih.gov/PubMed) was performed by the first author to search papers regarding gene-modified bone marrow mesenchymal stem cells for repair of articular cartilage injury using the English key words “cartilage, gene therapy, mesenchymal stem cells, tissue engineering, bioactive factor, vector”. After excluding papers with nonrelated and repetitive contents, 15 papers were suitable for final analysis. RESULTS AND CONCLUSION: Bone marrow mesenchymal stem cells have been widely used for repair of articular cartilage injury. Bone marrow mesenchymal stem cells with specific exogenous gene introduced by transgenic technology could acquire better therapeutic effects in treatment of articular cartilage injury.